| 周奕菁,方龙才.当归补血汤联合罗沙司他治疗CKD肾性贫血的临床疗效及对外周血HIF-α、HePc、EPO水平的影响[J].浙江中西医结合杂志,2024,34(12): |
| 当归补血汤联合罗沙司他治疗CKD肾性贫血的临床疗效及对外周血HIF-α、HePc、EPO水平的影响 |
| Clinical efficacy of Angelica sinensis blood replenishing soup combined with roxarestat in the treatment of renal anaemia in CKD and its effect on peripheral blood HIF-α, HePc and EPO levels |
| 投稿时间：2024-04-22 修订日期：2024-09-27 |
| DOI： |
| 中文关键词: 当归补血汤 罗沙司他 慢性肾脏病 肾性贫血 疗效 |
| 英文关键词:Angelica sinensis blood tonic soup Roxarestat Chronic kidney disease Renal anaemia Therapeutic efficacy |
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| 中文摘要: |
| 目的 观察当归补血汤联合罗沙司他治疗慢性肾脏病（CKD）肾性贫血的临床疗效及对外周血缺氧诱导因子-α（HIF-α）、铁调素（HePc）、促红细胞生成素（EPO）水平的影响。方法 选取我院2022年5月到2023.12收治的75例CKD肾性贫血患者，完全随机分为对照组（37例）、观察组（38例）。对照组给予标准剂量罗沙司他，观察组给予当归补血汤联合标准剂量罗沙司他治疗，连续治疗8周。比较两组疗效、安全性及中医症候评分、HIF-α、EPO、甲状旁腺激素（iPTH）、C反应蛋白（CRP）、铁指标、血常规水平差异。结果 观察组总有效率为92.11%高于对照组的72.97%，差异有统计学意义（P<0.05）。两组治疗前中医症候评分及HIF-α、EPO、iPTH、CRP、铁指标、血常规比较，差异无统计学意义（P＞0.05）。两组治疗后中医症候评分及HIF-α、iPTH、CRP、HePc均低于治疗前，观察组治疗后较对照组更低（P<0.05）；两组治疗后平均红细胞体积（MCV）、EPO、血红蛋白（Hb）、红细胞比容（Hct）、平均红细胞血红蛋白量（MCH）、红细胞计数（RBC）、转铁蛋白饱和度（TSAT）、血清铁蛋白（SF）高于治疗前，观察组治疗后较对照组更高（P<0.05）。观察组累计不良反应发生率为13.16%与对照组的8.11%比较，差异无统计学意义（P＞0.05）。结论 当归补血汤联合罗沙司他治疗CKD肾性贫血可纠正贫血，改善铁代谢，提高疗效。 |
| 英文摘要: |
| Objective Observing the clinical efficacy of Danggui Buxue Tang combined with rosuvastatin in treating renal anemia in chronic kidney disease (CKD) patients and its effects on peripheral blood hypoxia-inducible factor alpha (HIF-α), hepcidin (HePc), and erythropoietin (EPO) levels.Methods From May 2022 to December 2023, our hospital admitted 75 patients with renal anemia associated with chronic kidney disease (CKD), randomly divided into a control group (37 patients) and an observation group (38 patients). The control group received a standard dose of rosuvastatin, while the observation group was treated with Danggui Buxue Tang combined with standard dose rosuvastatin for 8 weeks. The study compared the efficacy, safety, Traditional Chinese Medicine (TCM) syndrome scores, levels of hypoxia-inducible factor alpha (HIF-α), erythropoietin (EPO), intact parathyroid hormone (iPTH), C-reactive protein (CRP), iron parameters, and complete blood count between the two groups.Results The overall effectiveness of the observation group was 92.11%, significantly higher than the 72.97% in the control group (P<0.05). There was no significant difference between the two groups in Traditional Chinese Medicine (TCM) syndrome scores, levels of hypoxia-inducible factor alpha (HIF-α), erythropoietin (EPO), intact parathyroid hormone (iPTH), C-reactive protein (CRP), iron parameters, and complete blood count before treatment (P>0.05). After treatment, the scores and levels of HIF-α, iPTH, CRP, and hepcidin (HePc) decreased in both groups, with lower values in the observation group (P<0.05). Post-treatment, the mean corpuscular volume (MCV), EPO, hemoglobin (Hb), hematocrit (Hct), mean corpuscular hemoglobin (MCH), red blood cell count (RBC), transferrin saturation (TSAT), and serum ferritin (SF) were higher than before treatment in both groups, with the observation group showing greater increases (P<0.05). The incidence of adverse reactions was 13.16% in the observation group compared to 8.11% in the control group, a difference that was not statistically significant (P>0.05).Conclusion Angelica sinensis blood tonic soup combined with roxarestat in the treatment of renal anaemia in CKD corrects anaemia, improves iron metabolism and enhances therapeutic efficacy. |
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