| 王叶萍,吴绿仙,应玲静,许博.粪钙卫蛋白和促胃液素在腹型过敏性紫癜患儿早期诊断中应用价值[J].浙江中西医结合杂志,2025,35(2): |
| 粪钙卫蛋白和促胃液素在腹型过敏性紫癜患儿早期诊断中应用价值 |
| The application value of fecal calprotectin and gastrin in the early diagnosis of children with abdominal allergic purpura |
| 投稿时间：2024-05-09 修订日期：2024-08-21 |
| DOI： |
| 中文关键词: 粪便钙卫蛋白 促胃液素 腹型过敏性紫癜 |
| 英文关键词:Fecal calprotectin Gastrin-17 Abdominal Henoch-Schonlein purpura |
| 基金项目:省医药卫生科技计划项目(2024KY1752)；金华市科学技术局重点课题(2022-3-130、2022-3-128)。 |
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| 中文摘要: |
| 目的 探讨粪钙卫蛋白（FC）、血清促胃液素(G-17)在腹型过敏性紫癜（HSP）患儿早期诊断中应用价值。方法 选取32例腹型HSP患儿为腹型组，32例单纯皮肤型HSP患儿为皮肤型组，另取同期来院健康体检儿童32例为对照组。比较三组患儿FC、G-17水平，利用Logistic回归分析腹型HSP发生的危险因素，并分析FC和G-17的相关性。采用ROC曲线分析FC、G-17单独检测及两者联合检测对腹型HSP的诊断价值。结果 腹型组FC水平高于皮肤型组、对照组（P<0.05），但G-17水平低于皮肤型组、对照组（P<0.05）。腹型HSP患儿急性期FC与G-17水平呈负相关（r=-0.456, P<0.05）。FC、G-17联合检测诊断腹型HSP的曲线下面积为0.921，显著高于两者单独检测（P<0.05）。结论 腹型HSP患儿急性期的FC高表达和血清G-17低表达可作为临床诊断的重要指标，两者联合检测对于儿童腹型HSP的早期诊断和干预具有重要意义。 |
| 英文摘要: |
| Objective To explore the application value of fecal calprotectin (FC) and serum gastrin (G-17) in the early diagnosis of children with abdominal allergic purpura (HSP).Method Thirty-two cases of abdominal HSP children were selected as the abdominal type group, 32 cases of simple skin-type HSP children were selected as the skin type group, and another 32 healthy children who came to the hospital for physical examination during the same period were selected as the control group.The levels of FC and G-17 in the three groups were compared, and logistic regression analysis was used to analyze the risk factors for the occurrence of abdominal HSP.The correlation between FC and G-17 was analyzed.Receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic value of FC, G-17, and their combination for abdominal HSP. Result The FC level in the abdominal group was higher than that in the skin group and the control group (P <0.05), but the G-17 level was lower than that in the skin group and the control group (P<0.05).The levels of FC and G-17 in children with abdominal HSP in the acute phase were negatively correlated (r=-0.456,P<0.05).The area under the curve (AUC) for the combined detection of FC and G-17 for diagnosing abdominal HSP was 0.921, significantly higher than that of either alone (P<0.05). Conclusion The high expression of FC and the low expression of serum G-17 during the acute phase in children with abdominal HSP can be taken as important indicators for clinical diagnosis, and the combined detection of both has significant significance for the early diagnosis and intervention of abdominal HSP in children. |
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