| 丁少杰,王鑫,吉学群.针刺对脑卒中后抑郁模型大鼠行为学影响的系统评价和Meta分析[J].浙江中西医结合杂志,2025,35(5): |
| 针刺对脑卒中后抑郁模型大鼠行为学影响的系统评价和Meta分析 |
| Influence of Acupuncture on the Behavior of a Rat Model of Post-Stroke Depression: A Systematic Review and Meta-Analysis |
| 投稿时间：2024-05-12 修订日期：2024-09-20 |
| DOI： |
| 中文关键词: 针刺 脑卒中后抑郁 动物实验 行为学 系统评价 meta分析 |
| 英文关键词:acupuncture post-stroke depression animal experiment behavior systematic review meta-analysis |
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| 中文摘要: |
| 目的：系统评价针刺对脑卒中后抑郁模型大鼠行为学的影响。方法：计算机检索CNKI、Wan-Fang Data、VIP、CBM、PubMed、Embase、Web of Science以及The Cochrane Library数据库，全面搜集针刺治疗脑卒中后抑郁模型大鼠随机对照动物实验，检索时限均为建库至2022年10月15日。2名研究人员独立完成文献
筛选、数据提取及偏倚风险评估。本研究的主要结局指标包括Longa评分、旷野实验（垂直运动和水平运动次数）和蔗糖水偏好实验（蔗糖水消耗百分比），次要指标包括水迷宫实验（逃避潜伏期）、强迫游泳实验（静止时间）和新奇摄食抑制实验（摄食抑制时间和食物消耗量）。采用Stata 14.0软件进行meta分析。结果：本文最终纳入15项研究。我们对其中3项指标进行meta分析，结果显示针刺能降低Longa评分[SMD=-1.61,95%CI:-2.06 to -1.16,P＜0.001]，提高水平运动次数[SMD=1.65,95%CI:1.09 to 2.21, P＜0.001;SMD=3.36,95%CI: 2.38 to 4.33,P＜0.001]、垂直运动次数[SMD=1.59,95%CI:1.15 to 2.04,P＜0.001; SMD=2.61,
95%CI:1.09 to 4.14, P=0.001; SMD=2.35,95%CI:1.53 to 3.16, P＜0.001]和蔗糖水消耗百分比[SMD=1.76, 95%CI:1.19 to 2.34, P＜0.001]；对其余4项指标进行描述性分析，结果显示针刺可缩短逃避潜伏期、静止时间和进食抑制时间，但对进食物消耗量无影响。结论：针刺对脑卒中后抑郁模型大鼠行为学能产生一定影响，包括降低Longa评分，提高水平和垂直运动次数、蔗糖水消耗百分比，缩短逃避潜伏期、静止时间和进食抑制时间。 |
| 英文摘要: |
| Objective: To systematically review the efficacy of acupuncture on the behavior of post-stroke depression (PSD) rats. Methods: Eight electronic databases (CNKI, Wan-Fang Database, VIP, CBM, PubMed, Embase,Web of Science and The Cochrane Library) were comprehensively searched to collect animal experiments on acupunc-
ture in the treatment of model rats with PSD from inception to October 15 2022. Two reviewers independently screened literature, extracted data and assessed risk bias of included studies. The primary outcomes included Longa score, Open-field test (number of vertical and horizontal movements) and Sucrose preference test (percentage of sucrose consumption), the secondary outcomes included Morris water maze test(escape latency), Forced swimming test(immobility time) and Novelty suppressed feeding test(feeding inhibition time and food consumption). Meta-analysis was performed by Stata 14.0 software. Results: 15 studies were finally included. Meta-analysis was performed in 3 indicators, the results showed that acupuncture can reduce Longa score(SMD: -1.61,95%CI: -2.06 to -1.16, P＜0.001), improve horizontal movements(SMD: 1.65,95%CI: 1.09 to 2.21, P＜0.001;SMD: 3.36,95%CI: 2.38 to 4.33, P＜0.001) , vertical movements(SMD:1.59, 95%CI: 1.15 to 2.04, P＜0.001; SMD: 2.61,95%CI: 1.09 to 4.14, P=0.001; SMD: 2.35,95%CI: 1.53 to 3.16, P＜0.001) and percentage of sucrose consumption (SMD: 1.76, 95%CI: 1.19 to 2.34, P＜0.001). Descriptive analysis was performed in the rest 4 indicators,and the result also showed that acupuncture can shorten escape latency,immobility time,feeding inhibition time, but had no effect on food cansumption. Conclusions: acupuncture has effect on behavior changes,including Longa score, horizontal and vertical movements, percentage of sucrose consumption, escape latency, immobility time, feeding inhibition time, except food consumption. |
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