| 张银.重复经颅磁刺激联合音乐疗法对轻中度阿尔茨海默病患者前瞻性记忆及精神行为症状的影响[J].浙江中西医结合杂志,2025,35(3): |
| 重复经颅磁刺激联合音乐疗法对轻中度阿尔茨海默病患者前瞻性记忆及精神行为症状的影响 |
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| 投稿时间：2024-05-29 修订日期：2025-01-14 |
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| 中文关键词: 重复经颅磁刺激 音乐疗法 阿尔茨海默病 前瞻性记忆 精神行为症状 |
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| 目的 探讨重复经颅磁刺激（repetitive transcranial magnetic，rTMS）联合音乐疗法对轻中度阿尔茨海默病（Alzheimer's Disease，AD）患者前瞻性记忆及精神行为症状的影响。方法 选取120例2022年1月至2024年1月绍兴市第七人民医院住院轻中度AD患者为研究对象，分为对照组、rTMS组、音乐疗法组及联合组，各30例。对照组予常规康复及治疗方法，rTMS组、音乐疗法组在对照组基础上分别联合rTMS、音乐疗法治疗，联合组在对照组基础上予rTMS联合音乐疗法治疗，疗程3个月。治疗前后分别使用AD评定量表认知分量表、简易精神状态检查量表、神经精神量表评分、AD行为病理评定量表、Rivermead行为记忆测试、剑桥前瞻性记忆测试量表评估患者的认知功能、精神行为症状及前瞻性记忆水平并比较两组间的差异，比较两组治疗后的临床疗效。结果 联合组AD评定量表认知分量表、神经精神量表评分及AD行为病理评定得分高于其余三组，差异有统计学意义（P<0.05）；联合组简易精神状态检查、Rivermead行为记忆测试、剑桥前瞻性记忆测试得分高于其余三组，差异有统计学意义（P<0.05）。联合组临床总有效率高于其余三组，差异有统计学意义（P<0.05）。结论 rTMS联合音乐疗法治疗轻中度AD患者的疗效较好，可恢复患者的认知功能，减轻患者的精神行为症状，并提高前瞻性记忆水平，促进患者康复。 |
| 英文摘要: |
| Objective To investigate the effects of repetitive transcranial magnetic stimulation (rTMS) combined with music therapy on prospective memory and psychobehavioral symptoms in patients with mild to moderate Alzheimer's Disease (AD). Methods A total of 120 patients with mild and moderate AD hospitalized in the Seventh People's Hospital of Shaoxing City from January 2022 to January 2024 were selected as the study objects and divided into control group, rTMS group, music therapy group and combination group, with 30 cases each. The control group was treated with conventional rehabilitation and treatment, the rTMS group and the music therapy group were treated with rTMS and music therapy on the basis of the control group, respectively, and the combination group was treated with rTMS and music therapy on the basis of the control group, and the course of treatment was 3 months. Before and after treatment, the cognitive subscale of AD Rating Scale, simple mental state Examination Scale, Neuropsychiatric scale score, AD Behavioral Pathological Rating Scale, Rivermead Behavioral memory test, Cambridge Prospective memory Test Scale were used to evaluate the cognitive function, mental behavior symptoms and prospective memory level of the patients. Results The scores of cognitive subscale, neuropsychiatric scale and behavioral pathological evaluation of AD in the combined group were higher than those in the other three groups, and the differences were statistically significant (P<0.05). The scores of simple mental state examination, Rivermead behavioral memory test and Cambridge prospective memory test in the combined group were higher than those in the other three groups, and the difference was statistically significant (P<0.05).The total clinical effective rate of the combined group was higher than that of the other three groups, and the difference was statistically significant (P<0.05). Conclusion rTMS combined with music therapy is effective in the treatment of mild and moderate AD patients, which can restore the cognitive function of patients, reduce the mental and behavioral symptoms of patients, improve the level of prospective memory, and promote the rehabilitation of patients. |
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