| 费佳伟,王耀.血清骨桥蛋白、碱性磷酸酶对结直肠癌肝转移患者肝动脉灌注化疗预后的影响[J].浙江中西医结合杂志,2025,35(5): |
| 血清骨桥蛋白、碱性磷酸酶对结直肠癌肝转移患者肝动脉灌注化疗预后的影响 |
| The effect of serum osteopontin and alkaline phosphatase on the prognosis of patients with colorectal cancer with liver metastasis undergoing hepatic artery infusion chemotherapy |
| 投稿时间：2024-05-31 修订日期：2024-11-12 |
| DOI： |
| 中文关键词: 结直肠癌 肝转移 化疗 预后 骨桥蛋白 碱性磷酸酶 |
| 英文关键词:Colorectal cancer Liver metastasis Chemotherapy Prognosis Osteopontin Alkaline phosphatase |
| 基金项目:湖州市科技计划公益性应用研究项目 编号：2019GY34 |
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| 中文摘要: |
| 目的探讨骨桥蛋白(OPN)、碱性磷酸酶(ALP)对结直肠癌肝转移患者肝动脉灌注化疗预后的影响。方法选择2021年1月-2023年12月医院就诊的结直肠癌肝转移患者76例,患者均接受肝动脉灌注化疗,化疗结束1周后评估患者预后并分组,患者入院病情稳定后,发放调查问卷调查主要资料,并于入院时及肝动脉灌注化疗结束后检测相关实验室指标水平,包括癌胚抗原(CEA)、骨桥蛋白(OPN)、癌抗原19-9(CA19-9)、碱性磷酸酶(ALP),重点分析血清OPN、ALP水平对患者预后的影响。结果较化疗前,患者化疗结束后CEA、OPN、CA19-9、ALP均有所降低(P＜0.05)；全部76例患者,预后良好22例,占比28.94%；不同预后患者的人口学资料及肿瘤分化程度、转移时期、肝外转移方面比较差异无统计学意义(P＞0.05)；预后不良组肝转移瘤直径≥5cm、肝转移多发占比高于预后良好组(P＜0.05)；经Logistic回归分析显示,肝转移瘤大小≥5cm、肝转移瘤多发、入院时CEA、OPN、ALP异常过表达均对结直肠癌肝转移患者肝动脉灌注化疗预后有影响,可能是其影响因素(OR＞1,P＜0.05)。结论OPN、ALP以及肝转移瘤大小≥5cm、肝转移瘤个数为多发可能与结直肠癌肝转移患者肝动脉灌注化疗预后相关,化疗前OPN、ALP异常过表达可能是其危险因素。 |
| 英文摘要: |
| Objective To investigate the effect of osteopontin (OPN) and alkaline phosphatase (ALP) on the prognosis of patients with colorectal cancer with liver metastasis after hepatic artery infusion chemotherapy.Method: A prospective study was conducted on 76 patients diagnosed with liver metastasis from colorectal cancer in hospitals from January 2021 to December 2023. All patients received hepatic artery infusion chemotherapy, and their prognosis was evaluated and grouped one week after the chemotherapy ended. After the patient"s condition was stable on admission, the main data of the questionnaire survey were issued, and the levels of relevant laboratory indicators were detected at the time of admission and after the end of hepatic artery infusion chemotherapy, including carcinoembryonic antigen (CEA), osteopontin (OPN), cancer antigen 19-9 (CA19-9), alkaline phosphatase (ALP). The effect of serum OPN and ALP levels on the prognosis of patients was analyzed.Results Compared with before chemotherapy, CEA, OPN, CA19-9 and ALP decreased after chemotherapy (P<0.05). Among all 76 patients, 22 had a good prognosis, accounting for 28.94%. There was no statisticalsignificant difference in demography data, tumor differentiation, metastasis stage and extrahepatic metastasis among patients with different prognosis (P>0.05). The diameter of liver metastases≥5cm and the proportion of multiple liver metastases in the poor prognosis group were higher than those in the good prognosis group (P<0.05). Logistic regression analysis showed that liver metastases with a size of≥5cm, multiple liver metastases, and abnormal overexpression of CEA, OPN, and ALP at admission all had an impact on the prognosis of colorectal cancer patients with liver metastasis after hepatic artery infusion chemotherapy, which may be the influencing factors (OR>1, P<0.05).Conclusion: OPN, ALP, as well as liver metastases with a size≥5cm and multiple liver metastases, may be related to the prognosis of colorectal cancer patients with liver metastasis after hepatic artery infusion chemotherapy. Abnormal overexpression of OPN and ALP before chemotherapy may be a risk factor and should be taken seriously. |
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