| 吴周汉,唐梅文,许永辉,吴周统.灸法联合中药保留灌肠治疗盆腔炎性疾病后遗症的疗效分析——一项Meta分析[J].浙江中西医结合杂志,2025,35(3): |
| 灸法联合中药保留灌肠治疗盆腔炎性疾病后遗症的疗效分析——一项Meta分析 |
| The Efficiency of moxibustion combined with traditional Chinese medicine retention enema in pelvic inflammatory disease sequelae -- a Meta-analysis |
| 投稿时间：2024-06-05 修订日期：2025-01-20 |
| DOI： |
| 中文关键词: 灸法 中药保留灌肠 盆腔炎性疾病后遗症 Meta分析 |
| 英文关键词:Moxibustion method traditional Chinese medicine retention enema pelvic inflammatory disease sequelae Meta-analysis |
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| 中文摘要: |
| 背景 盆腔炎性疾病后遗症病程较长,目前主流的抗生素治疗效果不佳,中西医结合治疗正在成为该类疾病的首选方案。目的 系统评价灸法联合中药保留灌肠疗法治疗盆腔炎性疾病后遗症(sequelae of pelvic inflammatory disease)的疗效。方法 利用医学主题词和自由词组合检索的方式,检索PubMed、Embase、Cochrane Library、 Web of Science、中国知网、万方数据库、维普中文科技期刊数据库、中国生物医学文献服务系统以及其他检索途径中收录的关于灸法联合中药保留灌肠疗法的随机对照试验(randomized controlled trial RCT),检索时限均限定为2000年1月1至2024年2月1日。由2位评审员独立完成文献筛选和数据提取,采用Cochrane偏倚风险评估工具对文献进行质量评价,并通过Rev Man 5.4.1和Stata 18.0软件进行Meta分析。结果 共纳入12篇文献,包含1061例患者,其中干预组564例,对照组497例。Meta分析结果显示,灸法联合中药保留灌肠疗法在治疗盆腔炎性疾病后遗症患者中的临床的总有效率［RR＝1.25,95％CI(1.12,1.40),P=0.000］,下腹部坠胀缓解时间［MD＝-2.93,95％CI(-4.12,-1.73),P=0.000］,腰骶部疼痛缓解时间［MD＝-3.02,95％CI(-5.40,-0.65),P=0.013］,阴道分泌物异常缓解时间［MD＝-3.47,95％CI(-3.83,-3.12),P=0.000］,中医证候评分［MD ＝-4.45,95％CI(-7.12,-1.77),P=0.001］,局部体征评分［MD＝-4.45,95％CI(-7.12,-1.77),P=0.001］方面,干预组优于对照组。结论 灸法联合中药保留灌肠疗法对盆腔炎性疾病后遗症的患者有较好的疗效。但目前该研究所纳入的样本量较小,仅有中文文献且文献证据等级偏低,需要更多大样本,多中心,高质量的临床研究加以论证。本研究已在PROSPERO注册,注册号(CRD42024521952)。 |
| 英文摘要: |
| Background The sequelae of pelvic inflammatory disease have a long course, and the current mainstream antibiotic treatment has a poor effect, and the treatment of integrated traditional Chinese and Western medicine is becoming the first choice for this kind of disease. Purpose Objective to systematically evaluate the efficacy of moxibustion combined with traditional Chinese medicine retention enema therapy in the treatment of sequelae of pelvic inflammatory disease. Methods We searched PubMed, EMBASE, Cochrane Library, web of science, CNKI, Wanfang database, VIP Chinese sci-tech journal database, China biomedical literature service system and other search methods for randomized controlled trials of moxibustion combined with traditional Chinese medicine retention enema therapy, which were included in PubMed, EMBASE, Cochrane Library, web of science, and other search methods. The search time limit was from January 1, 2000 to February 1, 2024. Two reviewers independently completed literature screening and data extraction. Cochrane bias risk assessment tool was used to evaluate the quality of the literature, and meta-analysis was performed by Rev Man 5.4.1 and Stata 18.0 software. Results A total of 12 literatures were included, including 1061 patients, including 564 cases in the intervention group and 497 cases in the control group. The results of meta-analysis showed that the clinical total effective rate of moxibustion combined with traditional Chinese medicine retention enema therapy in the treatment of pelvic inflammatory disease sequelae patients [RR=1.25, 95% CI (1.12,1.40), P=0.000], the relief time of lower abdominal distension [MD=-2.93, 95% CI (-4.12, -1.73), P = 0.000], the relief time of lumbosacral pain [MD=-3.02, 95% CI (-5.40, -0.65), P = 0.013], the relief time of abnormal vaginal secretions ［MD＝-3.47, 95％ CI(-3.83, -3.12),P=0.000］.the intervention group was better than the control group in terms of TCM Syndrome score [MD=-4.45, 95% CI (-7.12, -1.77), P=0.001] and local signs score [MD=-4.45, 95% CI (-7.12, -1.77), P=0.001]. Conclusion Moxibustion combined with traditional Chinese medicine retention enema therapy has good curative effect on patients with sequelae of pelvic inflammatory disease. However, at present, the sample size included in the study is small, there are only Chinese literature and the level of literature evidence is low, which needs more large samples, multi center, high-quality clinical research to demonstrate. This study has been registered with Prospero with registration number (CRD42024521952). |
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