| 刘露,王佳,陈春凤.酸枣仁汤联合舍曲林治疗青少年抑郁症伴睡眠障碍临床效果观察[J].浙江中西医结合杂志,2024,34(9): |
| 酸枣仁汤联合舍曲林治疗青少年抑郁症伴睡眠障碍临床效果观察 |
| Clinical Observation of Suanzaoren Decoction combined with Sertraline in the treatment of Adolescent Depression with Sleep disorder |
| 投稿时间：2024-06-08 修订日期：2024-07-17 |
| DOI： |
| 中文关键词: 酸枣仁汤 舍曲林 青少年抑郁症 睡眠障碍 |
| 英文关键词:Suanzaoren Decoction sertraline adolescent depression sleep disorder |
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| 中文摘要: |
| 目的:观察酸枣仁汤联合舍曲林治疗青少年抑郁症伴睡眠障碍的临床疗效。方法:选取我院2022年3月至2023年3月收治的60例青少年抑郁症伴睡眠障碍患者作为研究对象,采用随机数字法将其分为对照组和研究组,各30例,对照组采用舍曲林治疗,研究组采用舍曲林联合酸枣仁汤治疗。比较两组的治疗效果。于治疗前及治疗第4周、8周末,采用汉密尔顿抑郁量表(HAMD-17)、汉密尔顿焦虑量表(HAMA)评估情绪状态,采用匹兹堡睡眠质量指数(PSQI)评分评估睡眠,以及中医证候积分及不良反应发生率。结果:研究组的治疗总有效率高于对照组(P＜0.05);治疗后两组的HAMD、HAMA、PSQI评分均较治疗前下降(P均＜0.05),且研究组的HAMD、HAMA、PSQI评分均低于对照组(P均＜0.05)。治疗8周后,研究组的疲倦乏力、烦躁易怒、精神抑郁、失眠多梦积分低于对照组(P＜0.05)。治疗8周后,研究组的恶心呕吐、口干评分低于对照组(P＜0.05)。结论:酸枣仁汤联合舍曲林治疗青少年抑郁症伴睡眠障碍患者可增强疗效,可改善睡眠质量,缓解抑郁、焦虑情绪,且能减轻不良反应,安全性较高。 |
| 英文摘要: |
| Objective :To observe the clinical therapeutic effect of Suanzaoren Decoction combined with Sertraline in the treatment of adolescent depression with sleep disorder. Methods: A total of 60 adolescent patients with depression and insomnia admitted to our hospital from March 2022 to March 2023 were selected as research objects, and they were divided into control group and research group by random number method, with 30 cases in each group. The patients in the research group received Suanzaoren Decoction with sertraline, and those in the control group received sertraline. The therapeutic effect of the two groups was compared. Hamilton Depression Scale (HAMD-17) and Hamilton Anxiety Scale (HAMA) were used to assess emotional state before treatment and at the 4th and 8th week of treatment. Pittsburgh Sleep Quality Index (PSQI) score was used to assess sleep, as well as TCM syndrome score and incidence of adverse reactions. Results: The total effective rate of the study group was higher than that of the control group (P < 0.05). After 8 weeks of treatment, HAMD, HAMA and PSQI scores of both groups were decreased compared with those before treatment (P < 0.05), and HAMD, HAMA and PSQI scores of the study group were lower than those of the control group (P < 0.05). After 8 weeks of treatment, the scores of fatigue, irritability, depression, insomnia and dreaminess in the study group were lower than those in the control group (P < 0.05). After 8 weeks of treatment, the scores of nausea, vomiting and dry mouth in the study group were lower than those in the control group (P < 0.05). Conclusion: Suanzaoren Decoction combined with Sertraline in the treatment of adolescent patients with depression and sleep disorder has a significant effect,which can improve sleep quality, relieve depression and anxiety, and reduce adverse reactions. |
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