| 尤曦.血清GGT、FIB联合VH-IVUS诊断冠心病患者易损斑块的临床价值[J].浙江中西医结合杂志,2025,35(3): |
| 血清GGT、FIB联合VH-IVUS诊断冠心病患者易损斑块的临床价值 |
| Clinical value of serum GGT, FIB combined with VH-IVUS in the diagnosis of vulnerable plaques in patients with coronary heart disease |
| 投稿时间：2024-06-15 修订日期：2024-09-23 |
| DOI： |
| 中文关键词: γ-谷氨酰转移酶 纤维蛋白原 虚拟组织学-血管内超声 CHD 易损斑块 |
| 英文关键词:Gamma-glutamyl transferase Fibrinogen Virtual histology-intravascular ultrasound Coronary heart disease Vulnerable Plaque |
| 基金项目:]嘉兴市科技计划项目(编号:2021AD30066) |
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| 中文摘要: |
| 【】目的:探讨血清γ-谷氨酰转移酶(GGT)、纤维蛋白原(FIB)联合虚拟组织学-血管内超声(VH-IVUS)诊断冠心病(CHD)患者易损斑块的临床价值。方法:选取2021年1月~2022年12月在本院心内科进行治疗的CHD患者60例为研究对象,根据VH-IVUS检查结果将患者分为易损斑块组(n=22)和稳定板块组(n=38)；其中单支血管病变28例(A组),双支血管病变18例(B组),多支血管病变14(C组)。另取同期体检的健康志愿者60例为对照组,检测患者血清FIB、GGT水平及VH-IVUS检查,Logistic回归分析发生易损斑块的影响因素,ROC曲线分析血清GGT、FIB对CHD患者易损斑块的诊断价值。结果:与对照组比较,CHD组血清GGT、FIB水平显著升高(P＜0.05)；A组、B组、C组血清GGT、FIB水平依次升高(P＜0.05)；易损斑块组患者血清GGT、FIB水平显著高于稳定斑块组患者(P＜0.05)；GGT、FIB是发生易损斑块的危险因素(P＜0.05)；血清GGT、FIB水平诊断CHD患者易损斑块的AUC为0.897,联合诊断效能高于单一指标诊断(Z联合-GGT=1.994、Z联合-FIB=1.947,P=0.046、P=0.048)。结论:CHD易损斑块患者血清GGT、FIB水平升高,二者联合诊断CHD患者易损斑块的效能较高,为临床医师制定有针对性治疗方案提供可靠依据。 |
| 英文摘要: |
| Objective: To explore the clinical value of serum gamma-glutamyl transferase (GGT), fibrinogen (FIB) combined with virtual histology-intravascular ultrasound (VH-IVUS) in the diagnosis of vulnerable plaques in patients with CHD (CHD). Methods: Sixty patients with CHD who underwent treatment in the cardiology department of our hospital from January 2021 to December 2022 were selected as the study subjects, According to the results of VH-IVUS, the patients were divided into vulnerable plaque group (n=22) and stable plaque group (n=38). There were 28 patients with single-vessel disease (group A), 18 patients with double-vessel disease (group B), and 14 patients with multi-vessel disease (group C). Sixty healthy volunteers who underwent physical examination during the same period were selected as the control group; the levels of serum FIB and GGT were detected and VH-IVUS tests were performed; Logistic regression analysis was used to analyze the influencing factors of vulnerable plaque; Receiver operating characteristic was applied to analyze the diagnostic value of serum GGT and FIB for vulnerable plaque in patients with CHD; Results: Compared with the control group, the serum levels of GGT and FIB in the CHD group were significantly increased (P<0.05); the levels of serum GGT and FIB in group A, group B and group C increased in turn (P<0.05).; The levels of serum GGT and FIB in the vulnerable plaque group were significantly higher than those in the stable plaque group (P<0.05). GGT and FIB were independent risk factors for vulnerable plaque (P<0.05). Serum GGT, FIB level in the diagnosis of CHD patients of vulnerable plaques AUC is 0.897, the sensitivity was 92.45%, specificity of 73.68%, the efficacy of combined diagnosis is higher than that of single index diagnosis (Zcombination-GGT=1.994、Zcombination-FIB=1.947,P=0.046、P=0.048). Conclusion: The levels of serum GGT and FIB are increased in patients with coronary vulnerable plaque. The combination of GGT and FIB has a high efficacy in the diagnosis of vulnerable plaque in patients with CHD, which provides a reliable basis for clinicians to formulate targeted treatment plans. |
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