| 罗琼.强直性脊柱炎患者SFe、HLA-B27、DKK-1、ESR、CRP水平变化及其预测价值研究[J].浙江中西医结合杂志,2025,35(6): |
| 强直性脊柱炎患者SFe、HLA-B27、DKK-1、ESR、CRP水平变化及其预测价值研究 |
| Study on the changes and predictive value of levels of SFe, HLA-B27, DKK-1, ESR, CRP in patients with ankylosing spondylitis |
| 投稿时间：2024-06-19 修订日期：2025-01-21 |
| DOI： |
| 中文关键词: 强直性脊柱炎 铁蛋白 人类白细胞抗原B27 Dickkopf-1蛋白 红细胞沉降率 C-反应蛋白 预测价值 |
| 英文关键词:Ankylosing spondylitis Ferritin Human leukocyte antigen B27 Dickkopf-1 protein Red blood cell sedimentation rate C-reactive protein predictive value |
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| 中文摘要: |
| 【】目的 探讨强直性脊柱炎患者铁蛋白(SFe)、人类白细胞抗原B27(HLA-B27)、Dickkopf-1蛋白(DKK-1)、红细胞沉降率(ESR)、C-反应蛋白(CRP)水平变化及其预测价值。方法 选取2022年12月~2023年12月宁波市第六医院收治的120例强直性脊柱炎患者作为强直性脊柱炎组,另选取同期137名健康体检者作为健康对照组。比较两组临床资料、SFe、HLA-B27、DKK-1、ESR、CRP水平,将强直性脊柱炎患者纳入阳性,健康体检者纳入阴性,采用受试者工作特征(ROC)曲线分析SFe、HLA-B27、DKK-1、ESR、CRP对强直性脊柱炎的预测价值。结果 强直性脊柱炎组男性、酗酒占比为75.83%、10.83%,高于健康对照组的64.23%、4.38%(P<0.05),而两组年龄、体质量指数、病程、酗烟、饮茶等比较,差异无统计学意义(P>0.05)。强直性脊柱炎组血清SFe、ESR、CRP及HLA-B27阳性表达水平均高于健康对照组,血清DKK-1水平均低于健康对照组(P<0.05)。将强直性脊柱炎纳入阳性,健康体检者纳入阴性,SFe、HLA-B27、DKK-1、ESR、CRP及联合检测预测强直性脊柱炎的曲线下面积(AUC)分别为0.752、0.655、0.682、0.707、0.701、0.869,敏感度分别为70.83%、65.99%、70.83%、71.67%、67.50%、80.83%,特异度分别为66.42%、62.77%、64.23%、67.15%、70.80%、79.56%,其中联合检测的AUC最高(P<0.05)。结论 性别、酗酒可能与强直性脊柱炎有一定联系,而SFe、ESR、CRP、HLA-B27、DKK-1与强直性脊柱炎的发生具有密切关系,可为临床判断强直性脊柱炎的发生提供重要参考,其中联合检测的预测价值最高。 |
| 英文摘要: |
| Objective To explore the changes and predictive value of levels of ferritin (SFe), human leukocyte antigen B27 (HLA-B27), Dickkopf-1 protein (DKK-1), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) in patients with ankylosing spondylitis. Methods 120 patients with ankylosing spondylitis admitted to the Sixth Hospital of Ningbo City from December 2022 to December 2023 were selected as the ankylosing spondylitis group, and 137 healthy examinees during the same period were selected as the healthy control group. The clinical data, levels of SFe, HLA-B27, DKK-1, ESR, and CRP between two groups were compared, and include patients with ankylosing spondylitis as positive and healthy individuals as negative, the predictive value of SFe, HLA-B27, DKK-1, ESR, and CRP for ankylosing spondylitis were analyzed by receiver operating characteristic (ROC) curves. Results The proportion of males and alcoholics in the ankylosing spondylitis group were 75.83% and 10.83%, which were higher than 64.23% and 4.38% of the healthy control group (P<0.05). However, there was no statistically significant difference between the two groups in terms of age, body mass index, disease course, smoking and tea consumption (P>0.05). The levels of serum SFe, ESR, CRP, and positive expression of HLA-B27 in the ankylosing spondylitis group were higher than those in the healthy control group, and the levels of serum DKK-1 were lower than those in the healthy control group (P<0.05). The area under the curve (AUC) of SFe, HLA-B27, DKK-1, ESR, CRP, and combined detection for predicting ankylosing spondylitis were 0.752, 0.655, 0.682, 0.707, 0.701, and 0.869, with sensitivity of 70.83%, 65.99%, 70.83%, 71.67%, 67.50%, and 80.83%, respectively, and specificity of 66.42%, 62.77%, 64.23%, 67.15%, 70.80%, and 79.56%, respectively. Among them, the AUC of combined detection was the highest (P<0.05). Conclusion Gender and alcohol abuse might be associated with ankylosing spondylitis, while SFe, ESR, CRP, HLA-B27, DKK-1 were closely related to the occurrence of ankylosing spondylitis and could providing important references for clinical judgment of the occurrence of ankylosing spondylitis. Among them, the combined detection had the highest predictive value. |
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