| 俞欣欣,万海方.环泊酚与丙泊酚用于内镜粘膜下剥离手术全麻诱导与维持的随机对照研究[J].浙江中西医结合杂志,2025,35(2): |
| 环泊酚与丙泊酚用于内镜粘膜下剥离手术全麻诱导与维持的随机对照研究 |
| A randomized controlled study of ciprofol and propofol for general anesthesia induction and maintenance in endoscopic submucosal dissection |
| 投稿时间：2024-06-25 修订日期：2024-09-24 |
| DOI： |
| 中文关键词: 内镜下粘膜剥离术 环泊酚 丙泊酚 全麻的诱导与维持 |
| 英文关键词:endoscopic mucosal dissection ciprofol propofol induction and maintenance of general anesthesia |
| 基金项目: |
|
| 摘要点击次数: 298 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的 比较环泊酚和丙泊酚用于内镜粘膜下剥离术(Endoscopic submucosal dissection,ESD)全麻诱导与维持的效果。 方法 选择本院近期择期 ESD手术患者80例,男44例,女36例,年龄18-64岁,ASAI或II级。采用随机数字表法将患者分为两组:环泊酚组(A组)和丙泊酚组(B组),每组40例,麻醉诱导两组患者均依次给予舒芬太尼 0.4μg/kg 静脉注射,A组予环泊酚 0.4mg/kg 静脉注射,B组予丙泊酚2mg/kg静脉推注,罗库溴铵0.7mg/kg。维持阶段A组泵注环泊酚 0.6-1.8mg/kg/h ,B组泵注丙泊酚 3-9mg/kg/h,同时两组均泵注瑞芬太尼 0.05-0.15μg/kg/min。记录镇静成功例数、手术时间、诱导时间、苏醒时间,记录各时间点(T0:入室安静后基础值；T1:插管前即刻； T2:气管插管即刻；T3:手术开始时；T4:粘膜剥离时；T5:手术结束时；T6:拔管后即刻的平均动脉压(Mean arterial pressure,MAP)和心率(Heart rate,HR)。记录两组注射痛,术中低血压、心动过缓,苏醒延迟的发生情况。结果 与丙泊酚组相比较,环泊酚组麻醉诱导时间延长(P＜0.05),苏醒时间延长(P＜0.05),注射痛发生率明显降低(P＜0.05)。两组间的镇静成功率,术中低血压、心动过缓、苏醒延迟等不良反应无明显统计学意义。结论 环泊酚能有效应用于ESD全麻的诱导与维持,和丙泊酚比较,环泊酚诱导时间延长,苏醒时间延长,但注射痛发生率明显更低。 |
| 英文摘要: |
| 【】Objective to compare the effects of ciprofol and propofol on the induction and maintenance of general anesthesia in endoscopic submucosal dissection(ESD). Methods 80 patients with (44 males And 36 females, aged from 18 to 64 years, ASA I or II )underwent recent elective ESD surgery in our hospital.The patients were divided into two groups: ciprofol group A and propofol group B, with 40 cases in each group. In the induction stage ,Both groups were given sufentanil 0.4ug/kg , group A was given ciprofol 0.4mg/kg intravenously , group B was given propofol 2mg/kg intravenously, and rocuronium 0.7mg/kg intravenous for general anesthesia induction. in the maintenance stage, group A was given with ciprofol by pump 0.6-1.8mg/kg/h , group B was injected with propofol 3-9mg/kg/h. and remifentanil was injected 0.05-0.15ug/kg/min in both groups. The number of successful sedation cases, operation time, induction time and recovery time were recorded, and each time point was recorded (T0: basic value after quiet; T1: immediately before intubation; T2: Tracheal intubation immediately; T3: At the beginning of the operation(); T4: when the mucosa is detached; T5: At the end of the operation; T6: Mean arterial pressure (MAP) and heart rate (HR) immediately after extubation. The incidence of injection pain, intraoperative hypotension, bradycardia and delayed recovery were recorded in the two groups |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
