| 吴梁安.原发性高血压患者血清SFRP2、sSema4D水平与左心室肥厚的关系[J].浙江中西医结合杂志,2025,35(7): |
| 原发性高血压患者血清SFRP2、sSema4D水平与左心室肥厚的关系 |
| Relationship between serum SFRP2 and sSema4D levels with left ventricular hypertrophy in patients with essential hypertension |
| 投稿时间：2024-08-06 修订日期：2025-05-07 |
| DOI： |
| 中文关键词: 原发性高血压 分泌型卷曲相关蛋白2 可溶性信号素D 左心室肥厚 |
| 英文关键词:Essential hypertension Secreted frizzled related protein 2 Soluble semaphorin D Left ventricular hypertrophy |
| 基金项目:萧山区科技计划引导项目(2020313) |
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| 中文摘要: |
| 目的：探究原发性高血压(EH)患者血清分泌型卷曲相关蛋白2(SFRP2)、可溶性信号素D(sSema4D)水平与左心室肥厚(LVH)的关系。方法：选取本院2021年11月至2023年11月收治的EH患者179例,作为研究组,均行超声心动图检测,根据有无合并LVH分为LVH组和NLVH组；另选取本院同期健康体检者179例为对照组；ELISA检测SFRP2、sSema4D水平；Pearson法分析血清SFRP2、sSema4D与超声心动图指标的相关性；EH患者发生LVH的影响因素采用多因素Logistic回归分析；绘制ROC曲线分析血清SFRP2、sSema4D对EH患者发生LVH的评估价值。结果：研究组血清SFRP2水平显著低于对照组(P＜0.05),sSema4D水平显著高于对照组(P＜0.05)。LVH组血清SFRP2水平显著低于NLVH组(P＜0.05),sSema4D水平显著高于NLVH组(P＜0.05)。LVH组LVEDD、LVESD、LVEDV、LVESV、LVMI显著高于NLVH组(P＜0.05)。根据Pearson相关性分析得知,血清SFRP2与sSema4D呈负相关(P＜0.05),二者均与LVEDD、LVESD、LVEDV、LVESV、LVMI均有关(P＜0.05)。Logistic回归分析得知sSema4D、LVEDD、LVESD、LVEDV、LVESV、LVMI为影响EH患者发生LVH的危险因素(P＜0.05),SFRP2为保护因素(P＜0.05)。根据ROC曲线得知,血清SFRP2、sSema4D评估EH患者发生LVH的AUC为0.863、0.866,二者联合评估EH患者发生LVH的AUC为0.959,二者联合优于各自单独评估(Z联合vs SFRP2=2.601、Z联合vs sSema4D =2.585,P均＜0.05)。结论：EH患者血清SFRP2水平显著降低,sSema4D水平显著升高,二者与LVH有关,联合检测可有效提高LVH的评估价值。 |
| 英文摘要: |
| Objective: To investigate the relationship between serum secreted frizzled related protein 2 (SFRP2) and soluble semaphorin D (sSema4D) levels with left ventricular hypertrophy (LVH) in patients with essential hypertension (EH). Methods: A total of 179 EH patients admitted to our hospital from November 2021 to November 2023 were selected as the study group. According to the presence or absence of LVH, they were grouped into LVH group and NLVH group. In addition, 179 patients with physical examination in our hospital were selected as the control group. The levels of SFRP2 and sSema4D were detected by ELISA. Pearson method was used to analyze the correlation between serum SFRP2, sSema4D and echocardiographic indicators. Multivariate logistic regression analysis was used to analyze the influencing factors of LVH in EH patients. ROC curves were plotted to analyze the evaluation value of serum SFRP2 and sSema4D for LVH in EH patients. Results: The serum SFRP2 level in the study group was greatly lower than that in the control group (P<0.05), and the level of sSema4D in the study group was greatly higher than that in the control group (P<0.05). The serum SFRP2 level in the LVH group was greatly lower than that in the NLVH group (P<0.05), and the level of sSema4D in the LVH group was greatly higher than that in the NLVH group (P<0.05). The LVEDD, LVESD, LVEDV, LVESV, and LVMI in the LVH group were greatly higher than those in the NLVH group (P<0.05). According to Pearson correlation analysis, serum SFRP2 was negatively correlated with sSema4D (P<0.05), and both were negatively correlated with LVEDD, LVESD, LVEDV, LVESV, and LVMI (P<0.05). Logistic regression analysis showed that sSema4D, LVEDD, LVESD, LVEDV, LVESV, and LVMI were the risk factors for LVH in EH patients (P<0.05), and SFRP2 was a protective factor (P<0.05). According to the ROC curve, the AUC values of serum SFRP2 and sSema4D in evaluating LVH in EH patients were 0.863 and 0.866, respectively, the AUC of the combination of the two in evaluating LVH in EH patients was 0.959, the combination of the two was better than their individual evaluations (Z combination vs SFRP2=2.601, Z combination vs sSema4D=2.585, P<0.05). Conclusion: The serum SFRP2 level is greatly reduced and sSema4D level is greatly increased in EH patients. The two are related to LVH, and the combined detection can effectively improve the evaluation value for LVH. |
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