| 潘丽华,詹璐.MiRNA在儿童哮喘病理机制中的研究进展及应用[J].浙江中西医结合杂志,2025,35(7): |
| MiRNA在儿童哮喘病理机制中的研究进展及应用 |
| The Research Progress and Application of miRNA in the Pathogenesis Mechanism of Childhood Asthma |
| 投稿时间：2024-08-08 修订日期：2025-02-18 |
| DOI： |
| 中文关键词: miRNA 发病机制 生物标志物 儿童哮喘 |
| 英文关键词: |
| 基金项目: |
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| 中文摘要: |
| 支气管哮喘,简称哮喘,是一种气道慢性炎症性疾病,以多变可逆的气流受限及反复发作的喘息、气促、胸闷等症状为特征,常见于夜间、清晨加剧。该病在儿童期高发,近年来患病率显著上升,遗传与环境因素共同作用显著。MicroRNAs(miRNAs),作为短链非编码RNA,通过调控基因表达参与哮喘病理机制,尤其在炎症反应、免疫调节中扮演关键角色。研究发现,特定miRNAs在哮喘患者中存在差异表达,可能成为疾病诊断与治疗的潜在生物标志物。深入探索miRNA在儿童哮喘中的作用机制,对揭示疾病本质及开发新疗法具有重要意义。 |
| 英文摘要: |
| Asthma, also known as bronchial asthma, is a chronic inflammatory disease of the airways characterized by variable and reversible airflow obstruction and recurrent episodes of wheezing, dyspnea, and chest tightness, which are often aggravated at night and in the morning. It is prevalent in childhood and the incidence has increased significantly in recent years, with a significant contribution from both genetic and environmental factors. MicroRNAs (miRNAs), as short non-coding RNAs, play a crucial role in the pathogenesis of asthma by regulating gene expression. In particular, they play a key role in inflammatory responses and immune regulation. Studies have found that specific miRNAs are differentially expressed in asthma patients, which may serve as potential biomarkers for disease diagnosis and treatment. Understanding the role of miRNAs in pediatric asthma is of great significance in revealing the underlying mechanisms of the disease and developing new therapies. |
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