| 钱一铭.基于“诸寒收引，皆属于肾”之病机探讨通督针法、通痹方热熨在膝关节骨性关节炎（肾阳虚证）中的应用效果[J].浙江中西医结合杂志,2025,35(7): |
| 基于“诸寒收引，皆属于肾”之病机探讨通督针法、通痹方热熨在膝关节骨性关节炎（肾阳虚证）中的应用效果 |
|
| 投稿时间：2024-08-16 修订日期：2025-04-07 |
| DOI： |
| 中文关键词: 膝骨性关节炎 针刺 中药热熨 肾阳虚证 |
| 英文关键词:Knee osteoarthritis Prick Chinese medicine hot ironing Kidney-yang deficiency syndrome |
| 基金项目: |
|
| 摘要点击次数: 320 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的:观察通督针法、通痹方热熨在膝关节骨性关节炎中的应用效果。方法?? 将110例膝关节骨性关节炎患者按照随机数字表法分为观察组和对照组,各55例。对照组患者口服依托考昔片,观察组在对照组基础上给予通督针法、通痹方热熨治疗,2组均连续治疗4周。比较两组方案的临床效果、Lyshom膝部量表(LKS)评分、膝关节疼痛视觉模拟评分法(VAS)评分、患侧腿股肌微血管血流灌注量、软骨厚度、膝关节液中炎症因子[血小板反应蛋白-１(TSP-1)、白细胞介素-18(IL-18)]、血清中骨代谢因子 [软骨寡聚基质蛋白(COMP)、低氧诱导因子1α(HIF-1α)]水平变化,记录2组不良反应。结果:观察组的总有效率更高,达96.08%,较对照组的82.00%升高明显(P<0.05)；治疗后,2组LKS评分均较治疗前升高、VAS评分均较治疗前降低(P＜0.05),且观察组变化幅度大于对照组(P＜0.05)；2组MBP增加率、软骨厚度均较治疗前升高(P＜0.05),且观察组大于对照组(P＜0.05)；2组膝关节液中TSP-1、IL-18水平、血清中COMP、HIF-1α水平均较治疗前降低(P＜0.05),且观察组低于对照组(P＜0.05)。治疗过程中,两组均出现轻微不良反应。结论:通督针法、通痹方热熨有利于改善膝关节骨性关节炎功能,减轻疼痛,促进局部微循环,增加软骨厚度,抑制滑膜炎症、改善骨代谢,安全性好。 |
| 英文摘要: |
| Objective: To observe the effect of Tongdu acupuncture method and Tongbi decoction on knee osteoarthritis. Methods: A 110 patients with knee osteoarthritis were divided into observation group and control group according to random number table method, 55 cases in each group. Control group was given etonocoximab orally, observation group was given Tongdu acupuncture and Tongbi decoction heat ironing treatment on the basis of control group, both groups were treated continuously for 4 weeks. The clinical effects, Lyshom Knee Scale (LKS) score, visual analogue scale of knee pain (VAS) score, microvascular blood perfusion volume of femoral muscle of the affected leg, cartilage thickness, inflammatory factors in knee fluid [platelet-reactive protein-1 (TSP-1), interleukin-18 (IL-18)], and bone metabolic factors[cartilage oligomeric matrix protein (COMP), hypoxia inducible factor 1α(HIF-1α) ] were compared between the two groups,and adverse reactions were recorded in 2 groups. Results: The total effective rate of observation group was higher, reaching 96.08%, which was significantly higher than that of control group (82.00%) (P<0.05). After treatment, LKS score of 2 groups was higher than before treatment, VAS score was lower than before treatment (P<0.05), and the variation of the observation group is greater than that of the control group (P<0.05). The increase rate of MBP and cartilage thickness in 2 groups were higher than before treatment (P<0.05), and the observation group was higher than the control group (P<0.05). The levels of TSP-1 and IL-18 in knee fluid, COMP and HIF-1α in serum in 2 groups were lower than those before treatment (P<0.05), and the observation group was lower than the control group(P<0.05). During the treatment, mild adverse reactions occurred in both groups. Conclusion: Tongdu acupuncture method and Tongbi Decoction can improve the function of knee osteoarthritis, relieve pain, promote local microcirculation, increase cartilage thickness, inhibit synovial inflammation, improve bone metabolism, and have good safety. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
