| 柴欣.SGK1，APOB，ANGPTL4在心力衰竭合并心房颤动患者血清中的表达及其预后的评估价值[J].浙江中西医结合杂志,2025,35(5): |
| SGK1，APOB，ANGPTL4在心力衰竭合并心房颤动患者血清中的表达及其预后的评估价值 |
| The expression and prognostic value of SGK1, APOB, ANGPTL4 in the serum of patients with heart failure combined with atrial fibrillationChai Xin 1, Huang Qigang 2, Xu Xin 3 |
| 投稿时间：2024-09-11 修订日期：2025-01-09 |
| DOI： |
| 中文关键词: SGK1，APOB，ANGPTL4在心力衰竭合并心房颤动患者血清中的表达及其预后的评估价值 |
| 英文关键词:Heart failure Atrial fibrillation Serum and glucocorticoid induced kinase 1 Apolipoprotein B Angiopoietin like protein 4 Prognosis |
| 基金项目:浙江省卫生健康科技计划项目(2021KY1165) |
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| 中文摘要: |
| 【】目的:探究血清和糖皮质激素诱导蛋白激酶1(SGK1)、载脂蛋白B(APOB)、血管生成素样蛋白4(ANGPTL4)在心力衰竭(CF)合并心房颤动(AF)患者血清中的表达及其预后评估价值。方法:选取2022年1月~2023年9月本院收治的CF合并AF患者87例为合并AF组,根据CF合并AF患者预后是否良好,将合并AF组分为预后良好组和预后不良组。另选取同期本院收治的87例CF未合并AF者为未合并AF组。采用酶联免疫吸附法检测血清SGK1、APOB、ANGPTL4水平。CF合并AF患者预后的影响因素行Logistic多因素回归分析。血清SGK1、APOB、ANGPTL4对CF合并AF患者预后的预测效能分析行受试者工作特征(ROC)曲线。结果:与未合并AF组相比,合并AF组患者血清SGK1水平升高,APOB、ANGPTL4水平降低(P＜0.05)。对CF合并AF患者随访6个月,87例CF合并AF患者预后不良率为41.38%(36/87)。预后良好组和预后不良组在NYHA心功能分级上比较有差异(P＜0.05)；与预后良好组相比,预后不良组患者血清SGK1水平升高,APOB、ANGPTL4水平降低(P＜0.05)。Logistic多因素回归分析表明,Ⅲ/Ⅳ级NYHA心功能、血清SGK1是CF合并AF患者预后不良的危险因素,血清APOB、ANGPTL4是CF合并AF患者预后不良的保护因素(P＜0.05)。ROC曲线结果表明,血清SGK1、APOB、ANGPTL4及三者联合预测CF合并AF患者预后的曲线下面积(AUC)分别为0.858、0.894、0.916、0.990,三者联合预测CF合并AF患者预后的AUC高于SGK1、APOB、ANGPTL4单独预测(P＜0.05)。结论:CF合并AF患者血清SGK1水平升高,APOB、ANGPTL4水平降低,三者联合对CF合并AF患者预后的评估价值更高。 |
| 英文摘要: |
| Objective: To investigate the expression and prognostic value of serum and glucocorticoid induced kinase 1 (SGK1), apolipoprotein B (APOB), and angiopoietin like protein 4 (ANGPTL4) in patients with heart failure (CF) combined with atrial fibrillation (AF). Methods: From January 2022 to September 2023, 87 patients with CF combined with AF admitted to our hospital were regarded as the combined AF group. According to whether the prognosis of CF combined with AF patients was good, the combined AF group was separated into a good prognosis group and a poor prognosis group. Another 87 cases of CF without concomitant AF admitted to our hospital were regarded as the non combined AF group. Enzyme linked immunosorbent assay (ELISA) was applied to detect serum levels of SGK1, APOB, and ANGPTL4. Multivariate logistic regression was applied to analyze the influencing factors of prognosis in CF combined with AF. Receiver operating characteristic (ROC) curves were applied to analyze the predictive efficacy of serum SGK1, APOB, and ANGPTL4 for the prognosis of CF combined with AF. Results: The serum SGK1 level in the combined AF group was higher than that in the non combined AF group, while the serum APOB and ANGPTL4 levels were lower than those in the non combined AF group (P<0.05). After a 6-month follow-up of CF combined with AF patients, the poor prognosis rate of 87 CF combined with AF patients was 41.38% (36/87). There was a obvious difference in NYHA cardiac function grading between the good prognosis group and the poor prognosis group (P<0.05); the serum SGK1 level in the poor prognosis group was higher than that in the good prognosis group, while the serum APOB and ANGPTL4 levels were lower than those in the good prognosis group (P<0.05). Multivariate logistic regression analysis showed that NYHA functional class III/IV and serum SGK1 levels were risk factors for the prognosis of CF patients with AF, while serum APOB and ANGPTL4 levels were protective factors for the prognosis of CF patients with AF (P<0.05). ROC curve showed that the area under the curve (AUC) of serum SGK1, APOB, ANGPTL4, and their combined prediction for the prognosis of CF combined with AF patients was 0.858, 0.894, 0.916, and 0.990, respectively. The AUC of their combined prediction for the prognosis of CF combined with AF patients was higher than that of SGK1, APOB, and ANGPTL4 alone (P<0.05). Conclusion: Serum SGK1 level is elevated, and APOB and ANGPTL4 levels are decreased in patients with CF combined with AF. The combination of the three has a higher prognostic value for CF combined with AF. |
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