| 阮乃荣.阿尔茨海默病患者血清ZnT8，zonulin，LPE水平与病情及认知功能的关系[J].浙江中西医结合杂志,2025,35(7): |
| 阿尔茨海默病患者血清ZnT8，zonulin，LPE水平与病情及认知功能的关系 |
| Relationship between serum ZnT8, zonulin, and LPE levels in Alzheimer"s disease patients with the condition and cognitive function |
| 投稿时间：2024-09-11 修订日期：2024-12-12 |
| DOI： |
| 中文关键词: 阿尔茨海默病 锌转运蛋白8 连蛋白 溶血磷脂酰乙醇胺 认知功能 |
| 英文关键词:Alzheimer"s disease Zinc transporter 8 Zonulin Lysophosphatidylethanolamine Cognitive function |
| 基金项目:浙江省医药卫生科技计划项目，编号：2024KY347 |
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| 中文摘要: |
| 【】目的:探究阿尔茨海默病患者血清锌转运蛋白8(ZnT8)、连蛋白(zonulin)、溶血磷脂酰乙醇胺(LPE)水平与病情,认知功能的关系。方法:观察组选取2021年8月~2023年8月期间在本院收治的131例阿尔茨海默病患者,根据临床痴呆评定量表(CDR)将其分为轻度组(45例),中度组(51例),重度组(35例)。对照组为同期在本院行体检的119名健康者。采用ELISA对各组血清ZnT8、zonulin水平进行检测,高效液相色谱-串联质谱法检测血清LPE水平,比较观察组和对照组一般资料；Logistic回归分析影响发生阿尔茨海默病的相关因素；Pearson和Spearman法对阿尔茨海默病患者血清ZnT8、zonulin、LPE水平之间以及与MoCA评分的相关性进行分析。结果:观察组和对照组文化程度、吸烟史、饮酒史、高血压病史、高血脂病史、婚姻状况、TG等比较,差异不显著(P＞0.05),TC、HDL-C、LDL-C、MoCA评分等比较,差异显著(P＜0.05)。与对照组相比,观察组血清ZnT8、zonulin、LPE水平升高,差异显著(P＜0.05)。重度组、中度组血清ZnT8、zonulin、LPE水平较轻度组升高,且与中度组相比,重度组血清ZnT8、zonulin、LPE水平显著升高(P＜0.05)。TC、LDL-C、HDL-C、血清ZnT8、zonulin、LPE水平是发生阿尔茨海默病的影响因素(P<0.05)。Pearson分析显示,阿尔茨海默病患者血清ZnT8与zonulin、ZnT8与LPE、zonulin与LPE水平均呈正相关(P<0.05)；Spearman分析显示,MoCA评分与血清ZnT8、zonulin、LPE水平均呈负相关(P<0.05)。结论:阿尔茨海默病患者中血清ZnT8、zonulin、LPE水平升高且与患者病情,认知功能相关。 |
| 英文摘要: |
| Objective: To explore the relationship between serum levels of zinc transporter 8 (ZnT8), Zonulin, and lysophosphatidylethanolamine (LPE) with the condition and cognitive function in Alzheimer"s disease patients. Methods: The observation group included 131 Alzheimer"s disease patients admitted to Ningbo Municipal Kang Hospital and Ningbo University Affiliated Kangning Hospital from August 2021 to August 2023. They were separated into mild group (45 cases), moderate group (51 cases), and severe group (35 cases) according to the Clinical Dementia Rating Scale (CDR). The control group consisted of 119 healthy individuals who underwent physical examinations in Ningbo Municipal Kang Hospital and Ningbo University Affiliated Kangning Hospital during the same period. ELISA was applied to detect serum levels of ZnT8 and zonulin in each group, high-performance liquid chromatography tandem mass spectrometry was applied to detect serum LPE level, the general information was compared between the observation group and the control group; Logistic regression was applied to analyze the relevant factors affecting the occurrence of Alzheimer"s disease; Pearson and Spearman methods were applied to analyze the correlation between serum ZnT8, zonulin, LPE levels, and MoCA scores in Alzheimer"s disease patients. Results: There was no great difference in educational level, smoking history, alcohol consumption history, hypertension history, hyperlipidemia history, marital status, TG, etc. between the observation group and the control group (P>0.05), however, there was a great difference in TC, HDL-C, LDL-C, MoCA scores, etc (P<0.05). Compared with the control group, the serum levels of ZnT8, zonulin, and LPE in the observation group increased greatly (P<0.05). The serum levels of ZnT8, zonulin, and LPE in the severe and moderate groups were higher than those in the mild group, and compared with the moderate group, the serum levels of ZnT8, zonulin, and LPE in the severe group were greatly higher (P<0.05). TC, LDL-C, HDL-C, serum ZnT8, zonulin, and LPE levels were influential factors in the development of Alzheimer"s disease (P<0.05). Pearson analysis showed that there was a positive correlation between serum ZnT8 and zonulin, ZnT8 and LPE, and zonulin and LPE levels in Alzheimer"s disease patients (P<0.05); Spearman analysis showed that MoCA score was negatively correlated with serum levels of ZnT8, zonulin, and LPE (P<0.05). Conclusion: Serum levels of ZnT8, zonulin, and LPE are elevated in Alzheimer"s disease patients and are related to their condition and cognitive function. |
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