| 叶海潇,施雨莎,蒋越,林上助.基于数据挖掘探究林上助教授辨治慢性萎缩性胃炎的用药规律[J].浙江中西医结合杂志,2025,35(7): |
| 基于数据挖掘探究林上助教授辨治慢性萎缩性胃炎的用药规律 |
| Exploring Professor Lin Shang |
| 投稿时间：2024-09-11 修订日期：2024-12-15 |
| DOI： |
| 中文关键词: 数据挖掘 慢性萎缩性胃炎 用药规律 |
| 英文关键词:Data mining Chronic atrophic gastritis Medication pattern |
| 基金项目:1.浙江中医药大学附属医院科研专项(NO.2022FSYYZY28) ，2.浙江省中医药科技计划项目（NO.2024ZF141） |
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| 中文摘要: |
| 目的：通过数据挖掘探究浙江省名中医林上助教授辨治慢性萎缩性胃炎（CAG）的用药规律，总结其学术思想。方法：收集2018年1月至2021年12月林上助教授于浙江中医药大学附属温州市中医院门诊部治疗CAG患者的中药处方，借助中医传承计算平台V3.0，对处方中药进行统计分析，包括使用频次、归经、性味以及功效。采用Graphpad prime 8.0软件对高频中药剂量分布情况进行可视化分析。并进行聚类分析，归纳和总结用药规律。结果：筛选出671首方剂，共124味中药，其中高频中药为炙甘草、茯苓、佛手、白花蛇舌草、丹参等，药物四气以温、平为主，五味以苦、甘、辛居多，归经主入肺、脾、胃三经，获得关联规则及4个新处方。结论：林上助教授认为CAG的基础病机为气虚气滞兼血瘀、热毒，故化用经典方剂四君子汤，以炙甘草-茯苓-佛手-白花蛇舌草-丹参为基础方，意在益气行气，活血化瘀，清热解毒，调和气血，在临床提出“气虚络瘀型”这一证型。 |
| 英文摘要: |
| Objective: To explore the medication rules of Lin Shangzhu, a famous traditional Chinese medicine practitioner in Zhejiang Province, in treating chronic atrophic gastritis through data mining, and summarize his academic ideas on treating chronic atrophic gastritis. Methods: From January 2018 to December 2021, the prescriptions of traditional Chinese medicine for treating chronic atrophic gastritis by Professor Lin Shangzhu at the Wenzhou Traditional Chinese Medicine Hospital outpatient department affiliated with Zhejiang Chinese Medicine University were collected. The Chinese Medicine Inheritance Calculation Platform V3.0 was used to classify and count the Chinese medicines in the prescriptions, including its frequency, meridian, taste, and efficacy. Graphpad prime 8.0 was used for visual analysis of the dosage distribution of high-frequency Chinese medicines, and cluster analysis was conducted to summarize and conclude the medication rules of Professor Lin Shangzhu in treating chronic atrophic gastritis. Results: A total of 671 prescriptions were finally screened, involving 124 Chinese medicinal herbs. The Chinese medicines with higher use frequency were roasted licorice, Poria, Buddha""s hand, Oldenlandia diffusa, and Salvia miltiorrhiza, etc. The four qi of the drug are mainly warm and calm, the five flavors are mostly bitter, sweet, and pungent, and the attributive meridians mainly enter the lung, spleen and stomach meridians, obtaining the rules of association and 4 new prescriptions. Conclusion:User: Professor Lin Shang believes that the fundamental pathogenesis of chronic atrophic gastritis is qi deficiency, qi stagnation, along with blood stasis and heat-toxicity. Therefore, he reformulates the classic formula Si Jun Tang, using roasted licorice, Poria, Buddha""s hand, Oldenlandia diffusa, and Salvia miltiorrhiza as the foundational ingredients, with the intention of tonifying qi and promoting qi circulation, activating blood circulation to remove stasis, clearing heat and detoxifying, and harmonizing qi and blood. He has also proposed the "qi deficiency and blood stasis pattern" in clinical practice. |
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