| 周海腾.雌激素辅助治疗以阴性症状为主的绝经后女性精神分裂症的疗效及对患者认知功能、生活质量的影响[J].浙江中西医结合杂志,2025,35(4): |
| 雌激素辅助治疗以阴性症状为主的绝经后女性精神分裂症的疗效及对患者认知功能、生活质量的影响 |
| Therapeutic effect of estrogen assisted therapy on postmenopausal women with schizophrenia mainly characterized by negative symptoms, and its impacts on cognitive function and quality of life |
| 投稿时间：2024-09-23 修订日期：2025-02-08 |
| DOI： |
| 中文关键词: 雌激素 阴性症状 绝经后女性精神分裂症 认知功能 生活质量 |
| 英文关键词:Estrogen Negative symptoms Postmenopausal women with schizophrenia Cognitive function Quality of life |
| 基金项目:温州市科研项目(编号：Y20210765) |
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| 中文摘要: |
| 目的 探究雌激素辅助治疗以阴性症状为主的绝经后女性精神分裂症的疗效及对患者认知功能、生活质量的影响。方法 回顾性选取2022年6月~2023年5月在本院确诊的100例以阴性症状为主的绝经后女性精神分裂症患者为研究对象,根据治疗方法的不同分为常规治疗组(n=50)和联合组(n=50),常规治疗组采用奥氮平联合安慰剂药物进行治疗,联合组加用尼尔雌醇进行治疗。比较两组临床疗效、阴性症状评分指标[5个维度SANS评分]、认知功能指标[蒙特利尔认知评分量表(MoCA)评分]、生活质量指标[日常生活能力量表(ADL)、健康调查简表(SF-36)]及不良反应。结果 治疗后,联合组总有效率(84.00%)高于常规治疗组(66.00%)(P<0.05)；两组患者5个维度SANS评分均显著低于治疗前,且联合组低于常规治疗组(P<0.05)；两组患者的MoCA评分显著高于治疗前,且联合组高于常规治疗组(P<0.05)；两组患者的ADL评分、SF-36评分均显著高于治疗前,且联合组高于常规治疗组(P<0.05)；两组不良反应发生率无明显差异(P>0.05)。结论 雌激素辅助治疗以阴性症状为主的绝经后女性精神分裂症可以显著降低阴性症状相关指标评分,改善患者认知功能,提高患者生活质量,安全性较高,临床效果理想。 |
| 英文摘要: |
| Objective: To explore the therapeutic effect of estrogen assisted therapy on postmenopausal women with schizophrenia mainly characterized by negative symptoms, and its impacts on cognitive function and quality of life. Methods: From June 2022 to May 2023, 100 postmenopausal women with schizophrenia mainly characterized by negative symptoms diagnosed in our hospital were regarded as subjects. They were separated into a conventional therapy group (n=50) and a combination group (n=50) randomly. The conventional therapy group was treated with olanzapine combined with placebo, on this basis, the combination group added nilestriol. Two groups were compared of clinical efficacy, negative symptom scoring indicators [5 dimensions SANS score], cognitive function indicators [Montreal Cognitive Assessment (MoCA) score], quality of life indicators [activities of daily living (ADL), brief health survey (SF-36)], and adverse reactions. Results After therapy, the total effective rate of the combination group (84.00%) was higher than that of the conventional therapy group (66.00%) (P<0.05). The SANS scores of both groups in five dimensions were obviously lower than before therapy, and the combination group was lower than the conventional therapy group (P<0.05). The MoCA scores of both groups were obviously higher than before therapy, and the combination group was higher than the conventional therapy group (P<0.05). The ADL scores and SF-36 scores of both groups were obviously higher than before therapy, and the combination group was higher than the conventional therapy group (P<0.05). Adverse reactions were not obviously different between the two groups (P>0.05). Conclusion: Estrogen assisted therapy can obviously reduce the scores of negative symptom related indicators, improve cognitive function, and enhance quality of life in postmenopausal women with schizophrenia mainly characterized by negative symptoms. It has high safety and ideal effects. |
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