| 杨超群.度洛西汀联合氟伏沙明治疗50岁后首发女性重度抑郁症的效果和安全性研究[J].浙江中西医结合杂志,2026,36(2): |
| 度洛西汀联合氟伏沙明治疗50岁后首发女性重度抑郁症的效果和安全性研究 |
| Study on the efficacy and safety of Duloxetine combined with fluvoxamine in the treatment of first-episode female major depression after 50 years old |
| 投稿时间：2024-10-02 修订日期：2025-06-19 |
| DOI： |
| 中文关键词: 女性 中老年 重度抑郁症 度洛西汀 氟伏沙明 舍曲林 安全性 不良反应 |
| 英文关键词:female Middle and old age major depressive disorder Duloxetine Fluvoxamine Sertraline Safety Adverse reactions |
| 基金项目: |
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| 中文摘要: |
| 目的:探讨度洛西汀与氟伏沙明联合用于50岁后首发女性重度抑郁治疗的临床效果。方法:选取2020年11月~2022年2月我院女性精神疾病院区收治的67例临床诊断为首发重度抑郁症的患者作为受试者。随机分为两组,分别为观察组(n=35)和对照组(n=32)。对照组采用盐酸舍曲林单独用药治疗,观察组采用度洛西汀与氟伏沙明治疗,比较两组患者的治疗效果。结果:两组患者治疗前HAMD评分、PSQI评分和SHAPS评分无显著性差异(P＞0.05)。经过6周治疗,在HAMD评分方面,观察组受试者显著低于对照组(P＜0.05)。其中,在第1周和第3周两个时间节点时,观察组PSQI评分显著低于对照组(t＝3.306,P＝0.002；t＝8.731,P＜0.001)。治疗后3周和6周时间节点时,观察组受试者SHAPS评分显著低于对照组受试者(t＝9.991,P＜0.001；t＝10.764,P＜0.001)。观察组患者的治疗有效率(97.14%)显著高于对照组(84.38%)(?2＝6.772,P＝0.041)。两组患者不良反应发生率差异不显著(?2=0.172,P=0.504)。结论:度洛西汀和氟伏沙明均是目前临床上治疗抑郁症的有效方法,将两种药物联合应用可发挥药物协同作用,取得更好的用药效果,同时该联合用药方法具有良好的安全性。 |
| 英文摘要: |
| Objective: To investigate the clinical effect of Duloxetine combined with fluvoxamine in the treatment of severe depression in women after 50 years of age. Methods: Sixty-seven patients with first-episode major depression were selected from November 2020 to February 2022 in our hospital. They were divided into control and observation group,each group was 35, randomly . Patients in the control group were treated with sertraline alone, while those in the Observation Group were treated with duloxetine and fluvoxamine. Results: The scores of Hamd, PSQI and Shaps were not significantly different between the two groups before treatment (P > 0.05) . To treatment? after 6 week, in the observation group, the scores of HAMD were lower than the control group ,significantly (P < 0.05) . To treatment? after 1 and 3 weeks, the PSQI scores of observation group were lower than control group ,significantly (t = 3.306, P = 0.002; t = 8.731, P < 0.001) . To treatment? after 3 and 6 weeks, the PSQI scores of observation group were lower than control group ,significantly (t = 9.991, p < 0.001; t = 10.764, P < 0.001) . The observation group effective rate (97.14%) was higher than the control group (84.38%) ,significantly (?2 = 6.772, P = 0.041) . The two groups incidence of adverse reactions was no significant difference (?2 = 0.172, P = 0.504) . Conclusion: Duloxetine and fluvoxamine are both effective methods for the treatment of depression in clinical practice at present. The combination of the two drugs can play a synergistic role and achieve better drug effect. At the same time, the combination of the two drugs has good safety. |
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