| 周小凯.麝香保心丸联合“金三角”治疗方案对老年慢性心力衰竭患者心室重构及心功能的影响[J].浙江中西医结合杂志,2025,35(4): |
| 麝香保心丸联合“金三角”治疗方案对老年慢性心力衰竭患者心室重构及心功能的影响 |
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| 投稿时间：2024-10-17 修订日期：2025-02-17 |
| DOI： |
| 中文关键词: 心力衰竭 心功能 麝香保心丸 金三角方案 心室重构 随机对照 |
| 英文关键词:heart failure cardiac function Shexiang Baoxin Pill Golden Triangle therapy ventricular remodeling randomized controlled trial |
| 基金项目: |
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| 中文摘要: |
| 目的:分析麝香保心丸联合“金三角”治疗方案用于老年慢性心力衰竭治疗的效果。方法:纳入我院2023年1月至2023年12月收治的老年慢性心力衰竭患者196例,随机分为对照组(98例,“金三角”治疗方案)、麝香保心丸组(98例,“金三角”治疗方案+麝香保心丸),测量治疗前/后麝香保心丸组及对照组心功能、血管内皮功能及心室重构指标,评估临床疗效,记录胃肠道症状、肌肉酸痛等不良反应。结果:治疗后麝香保心丸组左心室射血分数(left ventricular ejection fraction,LVEF)高于对照组,左心室收缩末期内径(left ventricular end systolic dimension,LVESD)低于对照组(P＜0.05)；治疗后麝香保心丸组血清一氧化氮(Nitric Oxide,NO)水平高于对照组,血管性假血友病因子(Vascular Pseudohemophilia Factor,vWF)、内皮素-1(Endothelin-1,ET-1)水平低于对照组(P＜0.05)；治疗后麝香保心丸组左心室重构指数(left ventricular remodeling index,LVRI)、左心室后壁舒张末期厚度(1eft ventricular posterior wall end-diastolic thickness,LVPWd)显著低于对照组(P＜0.05)；麝香保心丸组总有效率显著高于对照组(P＜0.05)；胃肠道症状、肌肉酸痛、低血压等不良反应总发生率对比,麝香保心丸组与对照组无显著差异(P＞0.05)。结论:在常规“金三角”治疗方案的基础上加用麝香保心丸可显著改善老年慢性心力衰竭患者的心功能,减轻其血管内皮损伤,延缓心室重构,且联合给药无明显增毒表现。 |
| 英文摘要: |
| Objective: To analyze the effects of Shexiang Baoxin Pill combined with the "Golden Triangle" therapy in the treatment of elderly patients with chronic heart failure. Methods: A total of 196 elderly patients with chronic heart failure admitted to our hospital from January 2023 to December 2023 were enrolled and randomly divided into a control group (98 cases, receiving "Golden Triangle" therapy) and a Shexiang Baoxin Pill group (98 cases, receiving "Golden Triangle" therapy plus Shexiang Baoxin Pill). Cardiac function, vascular endothelial function, and ventricular remodeling indices were measured before and after treatment in both groups to assess clinical outcomes. Adverse reactions such as gastrointestinal symptoms and muscle soreness were also recorded. Results: After treatment, the left ventricular ejection fraction (LVEF) was higher in the Shexiang Baoxin Pill group than in the control group, while the left ventricular end-systolic dimension (LVESD) was lower (P < 0.05). Serum nitric oxide (NO) levels were higher in the Shexiang Baoxin Pill group compared to the control group, while vascular pseudohemophilia factor (vWF) and endothelin-1 (ET-1) levels were lower (P < 0.05). The left ventricular remodeling index (LVRI) and left ventricular posterior wall end-diastolic thickness (LVPWd) were significantly lower in the Shexiang Baoxin Pill group than in the control group after treatment (P < 0.05). The total effective rate was significantly higher in the Shexiang Baoxin Pill group than in the control group (P < 0.05). There was no significant difference in the overall incidence of adverse reactions such as gastrointestinal symptoms, muscle soreness, and hypotension between the two groups (P > 0.05). Conclusion: Adding Shexiang Baoxin Pill to the conventional "Golden Triangle" therapy can significantly improve cardiac function, reduce vascular endothelial injury, and delay ventricular remodeling in elderly patients with chronic heart failure, without significant additional toxicity. |
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