| 丁霞,马艳红,郭勇.健脾调气方对肝郁脾虚型癌因性疲乏患者临床疗效影响[J].浙江中西医结合杂志,2025,35(6): |
| 健脾调气方对肝郁脾虚型癌因性疲乏患者临床疗效影响 |
| Effect of Jianpi Tiaoqi prescription on the clinical effect of cancer induced fatigue of liver-qi Qi deficiency type |
| 投稿时间：2024-10-24 修订日期：2025-03-07 |
| DOI： |
| 中文关键词: 癌因性疲乏 肝郁脾虚 健脾调气方 临床疗效 生活质量 |
| 英文关键词:Cancer-related fatigue Liver depression and spleen deficiency Jianpi Tiaoqi formula Clinical effect Quality of life |
| 基金项目:湖州市科技计划项目（NO.2021GY61）；浙江省名中医郭勇学术经验传承与专科建设（No.2A11543） |
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| 中文摘要: |
| 目的 本研究通过分析健脾调气方对肝郁脾虚型癌因性疲乏患者临床疗效影响，以期为患者的诊疗提供更多新思路。方法 前瞻性选取2023年5月~2024年5月在浙江省安吉县中医医院接受治疗的肝郁脾虚型癌因性疲乏患者110例作为研究对象，依据随机数字表法分为观察组和对照组，各55例。对照组依据患者具体状况采取支持性对症治疗，观察组在对照组基础上应用健脾调气方，2组患者均持续治疗2周。记录患者干预前后中医证候评分、中医证候疗效、疲乏症状评分、生活质量和机体免疫功能情况。结果 观察组患者中医证候疗效为90.91%，高于对照组的70.91%（P＜0.05）。干预前2组患者中医证候评分、简易疲乏量表（BFI）评分、生活质量问卷疲劳量表（EORTC-QLQ-C30）评分和血清免疫指标比较无显著差异（P＞0.05）。干预后，观察组患者中医证候评分、BFI量表评分、EORTC-QLQ-C30量表各项评分、血清CD3+、CD4+水平以及CD4+/CD8+比值相比干预前和对照组升高，血清CD8+水平相比干预前和对照组降低（P＜0.05）。结论 健脾调气方可提高肝郁脾虚型癌因性疲乏患者的临床疗效，改善患者的生活质量和机体免疫功能。 |
| 英文摘要: |
| Objective This study analyzed the effect of Jianpi Tiaoqi prescription on the clinical effect of cancer fatigue patients with liver-qi Qi deficiency, in order to provide more new ideas for the diagnosis and treatment of patients. Methods A total of 110 patients with liver-stagnation and spleen-deficiency cancer-related fatigue who were treated in Anji County Hospital of Traditional Chinese Medicine of Zhejiang Province from May 2023 to May 2024 were prospectively selected as the research objects, and divided into observation group and control group according to random number table method, with 55 cases in each group. The control group received supportive symptomatic treatment according to the specific conditions of the patients, and the observation group received Jianpi Tiaoqi prescription on the basis of the control group. Both groups received continuous treatment for 2 weeks. TCM syndrome score, TCM syndrome effect, fatigue symptom score, quality of life and body immune function were recorded before and after the intervention. Results he curative effect of TCM syndrome in observation group was 90.91%, which was higher than that in control group (70.91%) (P<0.05). There were no significant differences in TCM syndrome score, Simple Fatigue Scale (BFI) score, quality of Life questionnaire Fatigue Scale (EORTC-QLQ-C30) score and serum immune indexes between 2 groups before intervention (P>0.05). After intervention, TCM syndrome score, BFI scale score, EORTC-QLQ-C30 scale score, serum CD3+, CD4+ level and CD4+/CD8+ ratio of patients in observation group were increased compared with those before intervention and control group, and serum CD8+ level was decreased compared with those before intervention and control group (P<0.05). Conclusion Strengthening spleen and regulating qi can improve the clinical efficacy, quality of life and immune function of patients with liver depression and spleen deficiency type cancer fatigue. |
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