| 凡岩岩,潘欢欢,雷振营.瑞马唑仑联合小剂量艾司氯胺酮在妇科日间手术中的应用效果[J].浙江中西医结合杂志,2026,36(2): |
| 瑞马唑仑联合小剂量艾司氯胺酮在妇科日间手术中的应用效果 |
| Effect of remazolam combined with low dose esketamine in gynecological day surgery |
| 投稿时间：2024-11-05 修订日期：2025-02-20 |
| DOI： |
| 中文关键词: 瑞马唑仑 艾司氯胺酮 妇科 日间手术 |
| 英文关键词:Remazolam Esketamine Gynecology Day surgery |
| 基金项目: |
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| 中文摘要: |
| 目的： 探讨瑞马唑仑联合小剂量艾司氯胺酮在妇科日间手术中的应用效果。方法： 选取2023年6月-2024年3月在我院妇科就诊并行择期日间手术的患者为研究对象，并按随机数字表法分为对照组和观察组。对照组行常规麻醉方案，观察组采用瑞马唑仑联合小剂量艾司氯胺酮的麻醉方案。收集两组患者一般资料，记录患者麻醉起效时间、麻醉时间、手术持续时间、睫毛反射消失时间、苏醒时间、自主呼吸恢复时间、麻醉术后恢复室（PACU）停留时间、诱导后1 min（T1）、3 min（T2）、5 min（T3）时MAP波动程度和HR的变化情况以及不良反应。结果： 与对照组比较，观察组麻醉起效时间、睫毛反射消失时间、麻醉苏醒时间及自主呼吸恢复时间明显缩短（均P<0.05），T1、T2、T3时MAP波动程度和T2、T3时HR变化值也明显减小（P<0.05）。观察组总不良反应发生率明显低于对照组（19.18% vs 6.85%；t=4.901，P=0.027）。结论： 瑞马唑仑联合小剂量艾司氯胺酮在妇科日间手术中效果显著，且安全性高，值得推广。 |
| 英文摘要: |
| ABSTRACT Objective To investigate the effect of remazolam combined with low dose esketamine in gynecological day surgery. Methods Patients receiving gynecological treatment in our hospital and undergoing elective day surgery from June 2023 to March 2024 were selected as the study objects, and were divided into control group and observation group according to random random number table method. The control group received conventional anesthesia, and the observation group received remazolam combined with low dose esketamine anesthesia. General data of the two groups of patients were collected. Anesthesia onset time, anesthesia time, operation duration, eyelash reflex disappearance time, recovery time of spontaneous respiration, PACU residence time, 1 min (T1), 3 min (T2), 5 min (T3) after induction were recorded MAP fluctuation degree and HR changes and adverse reactions. Results Compared with the control group, the onset time of anesthesia, the disappearance time of eyelash reflex, the recovery time of anesthesia and the recovery time of spontaneous respiration in the observation group were significantly shortened (all P<0.05), and the fluctuation degree of MAP at T1, T2 and T3 and the change value of HR at T2 and T3 were also significantly decreased (P<0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group (19.18% vs 6.85%; t=4.901, P=0.027). Conclusion Remazolam combined with low dose esketamine is effective and safe in gynecological day surgery, which is worth popularizing. |
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