| 史晓轩.麻黄碱复合预注法对全麻下腹腔镜子宫切除术患者顺苯磺酸阿曲库铵起效时间及血流动力学影响[J].浙江中西医结合杂志,2026,36(4): |
| 麻黄碱复合预注法对全麻下腹腔镜子宫切除术患者顺苯磺酸阿曲库铵起效时间及血流动力学影响 |
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| 投稿时间：2024-11-18 修订日期：2026-03-24 |
| DOI： |
| 中文关键词: 麻黄碱复合预注法 全麻下腹腔镜子宫切除术 顺苯磺酸阿曲库铵 起效时间 血流动力学影响 |
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| 中文摘要: |
| 【】目的:观察麻黄碱复合预注法对全麻下腹腔镜子宫切除术患者顺苯磺酸阿曲库铵起效时间及血流动力学的影响。方法:选取2021年5月至2024年5月期间在本中心就诊的84例择期行全麻下腹腔镜子宫切除术患者,按随机数字表法分为试验组(n=42)和对照组(n=42)。麻醉诱导:对照组给予静脉注射生理盐水10 ml,试验组给予静脉注射麻黄碱0.1 mg/kg+生理盐水至10 ml。记录顺苯磺酸阿曲库铵从注射插管剂量至达最大阻滞时的起效时间及气管插管条件等级；比较诱导前后各时间点的平均动脉压(MAP)和心率(HR)；统计不良反应的发生率。结果:试验组顺苯磺酸阿曲库铵起效时间较对照组快(P＜0.05)。两组TOFR比值差异无统计学意义(P＞0.05)。两组插管条件评级无差异(P＞0.05)。与诱导前比较,两组插管前即刻MAP均降低；在插管后1 min、插管后3 min 对照组的MAP和HR均下降(P＜0.05)；试验组在插管前即刻、插管后1 min、插管后3 min时MAP、HR均高于对照组(P均＜0.05)。两组不良反应总发生率比较无差异(P＞0.05)。结论:麻黄碱复合预注法可缩短全麻下腹腔镜子宫切除术患者顺苯磺酸阿曲库铵起效时间,且对血流动力学影响较小,安全性较高。 |
| 英文摘要: |
| 【 】 Objective:To observe the effect of ephedrine combined preinjection on the onset time and hemodynamics of atracurium cisenesulfonate in patients undergoing laparoscopic hysterectomy under general anesthesia.methods:A sample of 84 patients, who underwent elective laparoscopic hysterectomy procedures under general anesthesia within the Anesthesiology Department of Hangzhou Shulan Hospital between May 2021 and May 2024, were selected and subsequently randomized into two groups: the experimental group (n=42) and the control group (n=42), using the random number table method..Anesthesia induction: The control group was given intravenous injection of 10 ml of normal saline, and the experimental group was given intravenous injection of ephedrine 0.1mg /kg+ normal saline to 10 ml.The time of onset (the time from intravenous intubation dose of atracurium cisbenesulfonate to maximum block) and tracheal intubation rating were recorded; Comparisons were made regarding mean arterial pressure (MAP) and heart rate (HR) across various time points, both preceding and following the induction phase.; The incidence of adverse reactions was measured.Results:The onset time of atracurium cisbenzenesulfonate in experimental group was faster than that in control group (P < 0.05).There was no significant difference in TOFR ratio between the two groups (P > 0.05).There was no difference in the rating of intubation conditions between the two groups (P > 0.05).Compared with before induction, MAP immediately before intubation decreased in both groups. MAP and HR of control group decreased 1 min and 3 min after intubation (P < 0.05). MAP and HR of test groups were higher than those of control group immediately before intubation, 1 min after intubation and 3 min after intubation (P < 0.05).There was no difference in the total incidence of adverse reactions between the two groups (P > 0.05)..Conclusion:Combined ephedrine preinjection can shorten the onset time of atracurium cisbenesulfonate in patients undergoing laparoscopic hysterectomy under general anesthesia, and has little effect on hemodynamics and high safety. |
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