| 李敏静,陈晔,裘晨晖,张丽婷.血府逐瘀汤加味治疗AECOPD合并肺动脉高压的疗效观察及其对氧化应激的影响[J].浙江中西医结合杂志,2025,35(7): |
| 血府逐瘀汤加味治疗AECOPD合并肺动脉高压的疗效观察及其对氧化应激的影响 |
| Efficacy of Modified Xuefu Zhuyu Decoction on AECOPD Complicated with Pulmonary Arterial Hypertension and Its Effect on Oxidative Stress |
| 投稿时间：2024-11-27 修订日期：2025-04-07 |
| DOI： |
| 中文关键词: 血府逐瘀汤 慢性阻塞性肺疾病 肺动脉高压 氧化应激 疗效 |
| 英文关键词:Xuefu Zhuyu Decoction chronic obstructive pulmonary disease pulmonary arterial hypertension oxidative stress efficacy |
| 基金项目: |
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| 中文摘要: |
| 目的:观察血府逐瘀汤加味治疗慢性阻塞性肺疾病急性加重期（AECOPD）合并肺动脉高压（PAH）的临床疗效及其对氧化应激的影响。方法: 收集2022年1月—2024年6月于浙江中医药大学附属第二医院住院的AECOPD合并PAH患者共82例，随机分为中药组（40例）和对照组（42例）。对照组给予常规西医治疗，中药组常规西医治疗加用血府逐瘀汤加味。比较两组中医证候总积分、中医证候疗效、动脉血气、凝血指标、肺动脉收缩压、氧化应激/抗氧化应激指标的变化。结果:治疗14天后，中药组中医证候总积分低于对照组（P＜0.05），中药组总有效率95.00%，高于对照组总有效率85.71%（P＜0.05）；中药组氧合指数高于对照组，纤维蛋白原（FIB）、D二聚体和CRP低于对照组，氧化应激指标蛋白质羰基（PC）、丙二醛（MDA）、8羟基脱氧鸟苷（8-OHdG）低于对照组，抗氧化应激指标超氧化物歧化酶（SOD）和机体总抗氧化能力（T-AOC）高于对照组，差异均有统计学意义（P＜0.05）；两组肺动脉收缩压比较，差异无统计学意义（P＞0.05）。结论:血府逐瘀汤加味可以改善AECOPD合并PAH患者临床症状，提高氧合指数，减轻高凝状态，调节氧化应激失衡。 |
| 英文摘要: |
| Objective: To observe the clinical efficacy of modified Xuefu Zhuyu Decoction on acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated with pulmonary arterial hypertension (PAH) and its effect on oxidative stress. Methods: A total of 82 patients with AECOPD complicated with PAH admitted? from January 2022 to March 2024 was collected and randomly divided into Chinese medicine group (40 cases) and control group (42 cases). The control group was given routine treatment, and the Chinese medicine group was additionally given modified Xuefu Zhuyu decoction. The changes of TCM syndrome score and curative effect, arterial blood gas, coagulation indexes, pulmonary artery systolic pressure(PASP), oxidative stress and antioxidant stress indicators were compared between the two groups. Results: After 14 days of treatment, TCM syndrome score of the Chinese medicine group was lower than that of the control group (P < 0.05). The total effective rate of the Chinese medicine group was higher than that of the control group [95.00% vs 85.71%] (P < 0.05). The levels of oxygenation index and antioxidant stress indicators (SOD and T-AOC) in the Chinese medicine group were higher than that in the control group, and the levels of fibrinogen(FIB), D-dimer and oxidative stress indicators (PC, MDA and 8-OHdG) were lower than that in the control group, with significant difference (P < 0.05). There was no significant difference in PASP between the two groups (P＞0.05). Conclusion: Modified Xuefu Zhuyu decoction can improve the clinical symptoms of AECOPD complicated with PAH, increase oxygenation index, reduce hypercoagulable state and regulate oxidative stress imbalance. |
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