| 李晓晖.PLR、AGR、AAPR、PA在乙型肝炎肝硬化中的诊断价值分析[J].浙江中西医结合杂志,2026,36(5): |
| PLR、AGR、AAPR、PA在乙型肝炎肝硬化中的诊断价值分析 |
| Analysis of the diagnostic value of PLR, AGR, AAPR and PA in hepatitis B cirrhosis |
| 投稿时间：2024-11-28 修订日期：2026-03-11 |
| DOI： |
| 中文关键词: 乙型肝炎 肝硬化 血小板/淋巴细胞比值 白蛋白/球蛋白比值 白蛋白/碱性磷酸酶比值 前白蛋白 诊断价值 |
| 英文关键词:Hepatitis B Liver cirrhosis Platelet/lymphocyte ratio Albumin/globulin ratio Albumin/alkaline phosphatase ratio Prealbumin Diagnostic value |
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| 中文摘要: |
| 目的 探讨血小板/淋巴细胞比值(PLR)、白蛋白/球蛋白比值(AGR)、白蛋白/碱性磷酸酶比值(AAPR)、前白蛋白(PA)在乙型肝炎肝硬化中的诊断价值。方法 选取2021年1月至2024年3月我院收治的117例慢性HBV感染者为研究对象,其中49例慢性乙型肝炎纳入慢性乙型肝炎组,68例乙型肝炎肝硬化患者纳入肝硬化组,另选取同期健康体检者117名作为对照组。分析乙型肝炎肝硬化发生的危险因素采用多因素Logistic回归分析法进行,比较三组PLR、AGR、AAPR、PA水平,绘制受试者工作特征(ROC)曲线分析PLR、AGR、AAPR、PA在乙型肝炎肝硬化中的诊断价值。结果 结果显示,年龄>65岁、HBV感染病程>10年、一级亲属肝病史、蜘蛛痣为乙型肝炎肝硬化发生的危险因素(P<0.05)。对照组、慢性乙型肝炎组、肝硬化组PLR、AGR、AAPR、PA呈降低趋势(P<0.05)。将乙型肝炎肝硬化纳入阳性,慢性乙型肝炎纳入阴性,绘制ROC曲线分析PLR、AGR、AAPR、PA单独及联合检测对乙型肝炎肝硬化的诊断价值,曲线下面积(AUC)为0.813、0.785、0.720、0.760、0.734、0.940,联合检测最高(Z=2.857、3.093、4.375、3.479、3.937,P<0.05)结论 乙型肝炎肝硬化的危险因素包括年龄>65岁、HBV感染病程>10年、一级亲属肝病史、蜘蛛痣等,联合检测PLR、AGR、AAPR、PA在乙型肝炎肝硬化中的诊断价值较高。 |
| 英文摘要: |
| Objective To explore the diagnostic value of platelet/lymphocyte ratio (PLR), albumin/globulin ratio (AGR), albumin/alkaline phosphatase ratio (AAPR), prealbumin (PA) in hepatitis B cirrhosis. Methods 117 patients with chronic HBV infection admitted to our hospital from January 2021 to March 2024 were selected as the study objects, 49 patients with chronic hepatitis B were included in the chronic hepatitis B group, 68 patients with hepatitis B cirrhosis were included in the cirrhosis group, and 117 healthy physical examination subjects were selected as the control group during the same period. Multivariate Logistic regression analysis was used to analyze the risk factors of hepatitis B cirrhosis. Levels of PLR, AGR, AAPR, PA in the three groups were compared. Receiver Operating characteristic (ROC) curve was drawn to analyze the diagnostic value of PLR, AGR, AAPR, PA in hepatitis B cirrhosis. Results The results showed that age >65 years, HBV infection course >10 years, first degree relatives" history of liver disease, spider naevi were risk factors for hepatitis B cirrhosis (P<0.05). The PLR, AGR, AAPR and PA of the control group, the chronic hepatitis B group and the cirrhosis group showed a decreasing trend (P<0.05). Hepatitis B cirrhosis was considered as positive and chronic hepatitis B as negative. ROC curve was drawn to analyze the diagnostic value of PLR, AGR, AAPR and PA alone and in testing for hepatitis B cirrhosis. The area under the curve (AUC) was 0.813, 0.785, 0.720, 0.760, 0.734, 0.940, which was the highest in the combined detection (Z=2.857, 3.093, 4.375, 3.479, 3.937. P<0.05). Conclusion The risk factors for hepatitis B cirrhosis included age >65 years, HBV infection course >10 years, first-degree relatives" history of liver disease, spider navius, etc. Combined PLR, AGR, AAPR, PA were of high diagnostic value in hepatitis B cirrhosis. |
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