| 王长虹.他汀类西药联合枳实薤白桂枝汤对冠心病合并高血脂症者血管内皮功能的影响[J].浙江中西医结合杂志,2026,36(3): |
| 他汀类西药联合枳实薤白桂枝汤对冠心病合并高血脂症者血管内皮功能的影响 |
| The effect of statins combined with Hovenia Citrus and Allium cinnamon soup on vascular endothelial function in patients with coronary heart disease (CHD) combined with hyperlipidaemia. |
| 投稿时间：2024-12-03 修订日期：2025-03-31 |
| DOI： |
| 中文关键词: 他汀类西药 枳实薤白桂枝汤 冠心病合并高血脂症 血管内皮功能 |
| 英文关键词:statins Citrus aurantium dulcis and Allium cinnamonum soup coronary heart disease combined with hyperlipidaemia vascular endothelial function. |
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| 中文摘要: |
| 【】目的 探究对于冠心病(CHD)合并高血脂症患者采用他汀类西药与枳实薤白桂枝汤联合治疗对血管内皮功能的影响。方法 回顾性选取我院2023年2月~2024年2月收治的89例CHD合并高血脂患者进行研究,对其采用不同治疗方案分为对照组(他汀类西药治疗,n=44)与观察组(他汀类西药与枳实薤白桂枝汤联合治疗,n=45),观察两组研究对象的治疗效果、血管内皮功能与血脂水平,并对不同治疗方案的安全性进行评估。结果 治疗前,研究对象胸闷、心悸、胸痛以及气短的积分对比无差异,P＞0.05,治疗后观察组上述证候积分均低于对照组,P＜0.05；治疗前,研究对象内皮素- 1(ET-1)、血管内皮生长因子(VEGF)以及一氧化氮(NO)水平无差异,P＞0.05,治疗后,观察组ET-1水平低于对照组,VEGF、NO水平高于对照组,P＜0.05；治疗前,研究对象低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)与总胆固醇(TC)水平无差异,P＞0.05,治疗后,观察组LDL-C、TG以及TC水平均低于对照组,HDL-C水平较高,P＜0.05；治疗后,观察组不良反应发生率与对照组无差异(4.44%VS11.36%),P＞0.05。结论 对于CHD合并高血脂患者采用他汀类西药与枳实薤白桂枝汤联合治疗的临床疗效较好,可有效改善患者的血管内皮功能与血脂水平,且与单一使用西药相比并未增加不良反应的风险。 |
| 英文摘要: |
| 【】Objective To investigate the effects of statins and Allium cepa cinnamon soup on endothelial function in patients with coronary heart disease (CHD) combined with hyperlipidemia. Methods 89 patients with CHD combined with hyperlipidemia admitted to our hospital from February 2023 to February 2024 were retrospectively selected for the study, and they were divided into the control group (statin treatment, n=44) and the observation group (statin and Allium cepa cinnamon twig broth combination treatment, n=45) by using different treatment protocols to observe the therapeutic effects, vascular endothelial function, and lipid levels of the study subjects in the two groups, and to evaluate the safety of different treatment protocols. Evaluate the safety of different treatment options. Results Before treatment, there was no difference in the points of chest tightness, palpitation, chest pain and shortness of breath among the study subjects, P＞0.05; after treatment, the points of the above symptoms in the observation |
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