| 薛文静,魏艺,胡元会.基于数据挖掘探讨胡元会教授治疗心房颤动的临床处方用药规律[J].浙江中西医结合杂志,2025,35(12): |
| 基于数据挖掘探讨胡元会教授治疗心房颤动的临床处方用药规律 |
| Discussion on the clinical prescription and medication rule of Professor Hu Yuanhui in the treatment of atrial fibrillation based on Data Mining |
| 投稿时间：2024-12-08 修订日期：2025-09-10 |
| DOI： |
| 中文关键词: 心房颤动 数据挖掘 关联分析 用药规律 聚类分析 芪珀生脉颗粒 |
| 英文关键词:atrial fibrillation Data mining Association analysis Medication rules Cluster analysis Qi-Po-Sheng-Mai granules |
| 基金项目:中国中医科学院科技创新工程项目(CI2021A03011); 首都卫生发展科研专项项目(首发2022-1-4153) |
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| 中文摘要: |
| 目的：分析胡元会教授治疗心房颤动的组方用药规律及临床用药的核心处方。方法：基于2023年至2024年胡元会教授于中国中医科学院广安门医院门诊系统中的371个处方数据，使用 R 4.3.1、Cytoscape、VOSviewer等软件对符合纳入标准的中药复方进行频次统计、关联规则分析、系统聚类分析等。研究结果：纳入方剂371首，包含药物127味，药性以寒、平、温为主，药味以苦、辛、甘为主，归经以肝、脾、肺为主。高频中药前10位为茯苓、丹参、甘松、黄连片、蜜桑白皮、法半夏、蝉蜕、炒僵蚕、麸炒白术、玄参。关联规则分析显示出现频次最多的对药为“丹参-茯苓”；出现频次最多的角药则为“丹参-玄参-北沙参”。聚类分析集结合临床用药经验发现，心房颤动治疗药物分7类聚类效果较好，其中核心处方为芪珀生脉颗粒。结论：初步明确胡元会教授治疗心房颤动的用药规律，中药论治心房颤动以益气养阴、清热宁神、熄风止痉、化痰活血为治则，其中芪珀生脉颗粒为临床治疗房[基金项目：中国中医科学院科技创新工程项目(CI2021A03011); 首都卫生发展科研专项项目(首发2022-1-4153)
作者单位：1 310007浙江省杭州市，杭州市中医院老年病科；2100053 北京,中国中医科学院广安门医院心内科
通讯作者：胡元会,E-mail:huiyuhui55@sohu.com]颤的核心处方，为临床用药及处方研发提供依据。 |
| 英文摘要: |
| Guang'anmen Hospital of Chinese Academy of Traditional Chinese Medicine
Objective: to analyze the medication rules of Professor Hu Yuanhui's prescriptions for the treatment of atrial fibrillation and the core prescriptions of clinical medication. Methods: Based on the data of 371 prescriptions of Professor Hu Yuanhui in the outpatient system of Guang'anmen Hospital, Chinese Academy of traditional Chinese medicine from 2023 to 2024, the frequency statistics, association rule analysis, and system clustering analysis of traditional Chinese medicine compounds meeting the inclusion criteria were carried out using R 4.3.1, Cytoscape, vosviewer and other software. Research results: 371 prescriptions were included, including 127 kinds of drugs. The properties are mainly cold, flat and warm. The drug tastes are mainly bitter, pungent and sweet, and the meridians are mainly liver, spleen and lung. The top 10 high-frequency traditional Chinese medicines are Poria cocos, Salvia miltiorrhiza, Glycyrrhiza, Coptis chinensis tablets, honey mulberry white bark, Pinellia ternata, cicada slough, fried stiff silkworm, fried Atractylodes macrocephala with bran, and Scrophularia. Association rule analysis showed that the drug with the most frequent occurrence was "Danshen-Poria cocos"; The horn drug with the most frequent occurrence is "Salvia miltiorrhiza-Radix Scrophulariae-Radix Glehniae". The cluster analysis set combined with clinical medication experience found that the therapeutic drugs for atrial fibrillation were classified into seven categories with good clustering effect, and the core prescription was Qi-Po-Sheng-Mai granules Conclusion: the medication rule of Professor Hu Yuanhui in the treatment of atrial fibrillation is preliminarily clarified. The treatment of atrial fibrillation with traditional Chinese medicine is based on Supplementing Qi and nourishing Yin, clearing heat and tranquilizing mind, calming wind and spasm, resolving phlegm and activating blood circulation. Qi-Po-Sheng-Mai granules is the core prescription of clinical treatment of atrial fibrillation, and provides the basis for clinical medication and prescription development. |
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