| 邬佳辇.自拟桑杏苡甘汤辅助西药治疗儿童急性鼻窦炎肺经风热证的临床研究[J].浙江中西医结合杂志,2025,35(7): |
| 自拟桑杏苡甘汤辅助西药治疗儿童急性鼻窦炎肺经风热证的临床研究 |
| Clinical study on the use of self-designed Sang Xing Mao Gan Tang as an adjuvant therapy for children with acute sinusitis and lung meridian wind heat syndrome in Western medicine |
| 投稿时间：2024-12-09 修订日期：2025-02-27 |
| DOI： |
| 中文关键词: 急性鼻窦炎 儿童 肺经风热证 自拟桑杏苡甘汤 糠酸莫米松鼻喷雾剂 阿奇霉素 |
| 英文关键词:Acute sinusitis Children Lung meridian wind heat syndrome Self made Sang Xing Mao Gan Tang Mometasone furoate nasal spray Azithromycin |
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| 中文摘要: |
| 目的 前瞻性研究观察自拟桑杏苡甘汤辅助西药治疗儿童急性鼻窦炎肺经风热证的临床疗效。方法 采用随机数字表法将宁波市海曙区中医医院收治的86例急性鼻窦炎患儿分为观察组与对照组,每组43例,观察组剔除1例,对照组剔除1例,最终2组完成研究者各42例。对照组给予西药糠酸莫米松鼻喷雾剂、阿奇霉素治疗,观察组在对照组基础上采用自拟桑杏苡甘汤辅助治疗,连续治疗4周后评估2组临床疗效、中医证候积分、血清炎症因子水平、生活质量及不良反应发生率。结果 治疗4周后,观察组总有效率92.86%优于对照组76.19%(P＜0.05)；治疗4周后,2组中医证候积分、鼻腔鼻窦结局测试-20(SNOT-20)量表评分均低于治疗前(P＜0.05),观察组各项评分均低于对照组(P＜0.05)；治疗4周后,2组血清超敏-C反应蛋白(hs-CRP)、白细胞介素-6(IL-16)、肿瘤坏死因子-α(TNF-α)水平均低于治疗前(P＜0.05),观察组各指标水平均低于对照组(P＜0.05)；对照组与观察组不良反应发生率分别为9.52%、7.14%,组间无明显差异(P＞0.05)。结论? 自拟桑杏苡甘汤辅助西药治疗儿童急性鼻窦炎肺经风热证疗效确切,可有效改善患儿症状体征,下调外周血清炎症水平减轻炎症反应,提高其生活质量,且药物安全性高。 |
| 英文摘要: |
| Objective: A prospective study was conducted to observe the clinical efficacy of self formulated Sang Xing Mao Gan Tang as an adjuvant therapy for children with acute sinusitis and lung meridian wind heat syndrome. Methods:The used a random number table to divide 86 children with acute sinusitis admitted to Ningbo Haishu District Traditional Chinese Medicine Hospital into an observation group and a control group, with 43 cases in each group. One case was excluded from the observation group and one case was excluded from the control group. Finally, 42 cases were completed in each group. The control group was treated with western medicine mometasone furoate nasal spray and azithromycin, and the observation group was assisted by the self prepared Sangxing Yigan Decoction on the basis of the control group. After four weeks of continuous treatment, the clinical efficacy, TCM syndrome score, serum inflammatory factors [hs-CRP, IL-16, TNF - α] level, quality of life [Nasal and Nasal Sinus Outcomes Test -20 (SNOT-20) scale] and the incidence of adverse reactions of the two groups were evaluated. Results:After 4 weeks of treatment, the total effective rate of the observation group was 92.86%, which was better than the control group"s 76.19% (P<0.05); After 4 weeks of treatment, the scores of traditional Chinese medicine syndrome and SNOT-20 scale in both groups were lower than before treatment (P<0.05), and the scores of various items in the observation group were lower than those in the control group (P<0.05); After 4 weeks of treatment, the levels of serum high-sensitivity C-reactive protein (hs CRP), interleukin-6 (IL-16), and tumor necrosis factor alpha (TNF - α) in both groups were lower than before treatment (P<0.05), and the levels of various indicators in the observation group were lower than those in the control group (P<0.05); The incidence of adverse reactions in the control group and observation group was 9.52% and 7.14%, respectively, with no significant difference between the groups (P>0.05).Conclusion: The self-designed Sang Xing Mao Gan Tang, combined with Western medicine, has a definite therapeutic effect on children with acute sinusitis and lung meridian wind heat syndrome. It can effectively improve the symptoms and signs of children, lower peripheral serum inflammation levels, reduce inflammatory reactions, improve their quality of life, and has high drug safety. |
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