| 叶海燕.血清galectin-3、BDNF、NGF在双相情感障碍患者临床诊断中的应用价值[J].浙江中西医结合杂志,2026,36(7): |
| 血清galectin-3、BDNF、NGF在双相情感障碍患者临床诊断中的应用价值 |
| The clinical diagnostic value of serum galectin-3, BDNF, and NGF in patients with bipolar disorder |
| 投稿时间：2024-12-17 修订日期：2026-06-03 |
| DOI： |
| 中文关键词: 双相情感障碍 半乳糖凝集素 脑源性神经营养因子 神经生长因子 |
| 英文关键词:Bipolar disorder Galectin Brain-derived neurotrophic factor nerve growth factor |
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| 中文摘要: |
| 【】目的 探究血清半乳糖凝集素(galectin-3)、脑源性神经营养因子(BDNF)、神经生长因子(NGF)在双相情感障碍(BD)患者临床诊断中的应用价值。方法 选取2021年4月至2024年4月与我院进行治疗的98例BD患者为研究对象纳入BD组,另选取同期于我院进行体检的98例健康志愿者纳入健康组,并根据临床总体印象-严重度量表(CGI-S)评分将BD组患者分为轻度组、中度组和重度组。对比BD组和健康组患者临床资料及血指标,轻度、中度和重度三组患galectin-3、BDNF、NGF、尿酸(UA)和游离甲状腺素4(FT4)水平,Pearson相关分析分析其与汉密顿抑郁量表(HAMD)、杨氏躁狂评定量表(YMRS)评分的相关性,并绘制受试者工作特征(ROC)曲线分析galectin-3、BDNF、NGF、UA和FT4水平和联合检测对BD患者及病情的诊断价值。结果 BD组和健康组患者年龄、性别、体质量指数、病程、受教育年限和婚姻状况等临床一般资料比较,均差异无统计学意义(P>0.05)；BD组患者galectin-3、UA和FT4水平均高于健康组,均差异有统计学意义(P<0.05)；BD组患者BDNF和NGF水平均低于健康组,均差异有统计学意义(P<0.05)。重度组BD患者galectin-3、UA和FT4水平高于中度组和轻度组,且中度组高于轻度组,有统计学差异(P<0.05)；重度组BD患者BDNF和NGF水平均低于中度组和轻度组,且均中度组低于轻度组,有统计学差异(P<0.05)。重度组BD患者HAMD和YMRS评分均高于中度组和轻度组,且均中度组高于轻度组,有统计学差异(P<0.05)。Pearson相关分析显示galectin-3、UA和FT4与BD患者HAMD和YMRS评分均呈正相关(P<0.05),BDNF和NGF与BD患者HAMD和YMRS评分均负相关(P<0.05)。经ROC曲线分析,galectin-3、BDNF、NGF、UA、FT4及五者联合诊断均对BD患者有较高诊断价值,且联合诊断的预测价值最高,AUC值分别为0.865、0.939、0.781、0.762、0.899、0.992；galectin-3、BDNF、NGF、UA、FT4及五者联合诊断均对BD患者病情程度有较高诊断价值,且联合诊断的预测价值最高,AUC值分别为0.784、0.775、0.754、0.733、0.766、0.964。结论 血清galectin-3、BDNF、NGF、UA、FT4水平与BD的发生及病情严重程度密切相关,均对BD的发生及病情严重程度有较高诊断价值,且联合诊断价值更高。 |
| 英文摘要: |
| Objective Exploring the clinical diagnostic value of serum galectin-3, brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) in patients with bipolar disorder (BD).Methods 98 BD patients who received treatment at our hospital from April 2021 to April 2024 were selected as the study subjects and included in the BD group. Additionally, 98 healthy volunteers who underwent physical examinations at our hospital during the same period were selected and included in the healthy group. Based on the Clinical General Impression Severity Scale (CGI-S) score, BD patients were divided into mild, moderate, and severe groups. Comparing the clinical data and blood indicators of patients in the BD group and the healthy group, the levels of galectin-3, BDNF, NGF, uric acid (UA), and free thyroxine 4 (FT4) were measured in the mild, moderate, and severe groups. Pearson correlation analysis was performed to analyze their correlation with the Hamilton Depression Rating Scale (HAMD) and Young"s Mania Rating Scale (YMRS) scores, and receiver operating characteristic (ROC) curves were plotted to analyze the diagnostic value of galectin-3, BDNF, NGF, UA, and FT4 levels and combined detection for BD patients and their condition.Results There was no statistically significant difference in clinical general data such as age, gender, body mass index, disease duration, education years, and marital status between the BD group and the healthy group (P>0.05); The levels of galectin-3, UA, and FT4 in the BD group were higher than those in the healthy group, and the differences were statistically significant (P<0.05); The levels of BDNF and NGF in the BD group were lower than those in the healthy group, and the differences were statistically significant (P<0.05). The levels of galectin-3, UA, and FT4 in severe BD patients were higher than those in moderate and mild groups, and the moderate group was higher than the mild group, with statistical differences (P<0.05); The levels of BDNF and NGF in severe BD patients were lower than those in moderate and mild groups, and the moderate group was lower than the mild group, with statistical differences (P<0.05). The HAMD and YMRS scores of severe BD patients were higher than those of moderate and mild groups, and the moderate group was higher than the mild group, with statistical differences (P<0.05). Pearson correlation analysis showed that galectin-3, UA, and FT4 were positively correlated with HAMD and YMRS scores in BD patients (P<0.05), while BDNF and NGF were negatively correlated with HAMD and YMRS scores in BD patients (P<0.05). According to ROC curve analysis, galectin-3, BDNF, NGF, UA, FT4, and their combined diagnosis all have high diagnostic value for BD patients, and the combined diagnosis has the highest predictive value, with AUC values of 0.865, 0.939, 0.781, 0.762, 0.899, and 0.992, respectively; Galectin-3, BDNF, NGF, UA, FT4, and their combined diagnosis all have high diagnostic value for the severity of BD patients, and the combined diagnosis has the highest predictive value, with AUC values of 0.784, 0.775, 0.754, 0.733, 0.766, and 0.964, respectively.Conclusion The levels of serum galectin-3, BDNF, NGF, UA, and FT4 are closely related to the occurrence and severity of BD. They all have high diagnostic value for the occurrence and severity of BD, and the combined diagnostic value is even higher. |
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