| 董新英.导痰汤加减联合常规西药治疗慢阻肺急性加重期疗效及对炎性因子指标的影响[J].浙江中西医结合杂志,2026,36(1): |
| 导痰汤加减联合常规西药治疗慢阻肺急性加重期疗效及对炎性因子指标的影响 |
| The therapeutic effect of modified Dao Tan Tang combined with conventional Western medicine on acute exacerbation of chronic obstructive pulmonary disease and its impact on inflammatory factor indicators |
| 投稿时间：2024-12-25 修订日期：2025-11-26 |
| DOI： |
| 中文关键词: 导痰汤加减 慢阻肺急性加重期 炎性因子 肺通气功能 血气指标 |
| 英文关键词: |
| 基金项目:湖州市科技局一般项目(2022GYB20) |
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| 中文摘要: |
| 目的：观察将导痰汤加减与常规西药联合用于治疗慢阻肺急性加重期的临床疗效。方法：按随机数字表法将102 例慢阻肺急性加重期患者分成两组,对照组给予常规西药治疗,治疗组给予导痰汤加减联合常规西药治疗。比较两组中医证候积分、改良版呼吸困难问卷(mMRC 评分)、慢性阻塞性肺疾病评测量表(CAT)评分、血气指标[动脉血氧分压(PaO2)、动脉二氧化碳分压(PaCO2)、氧饱和度(SaO2)]、肺通气功能指标(气道阻力、比气道阻力、比气道传导率)、炎性因子指标变化,统计两组临床疗效及不良反应。结果：治疗后,两组中医证候积分、mMRC 评分、CAT评分、PaCO2、气道阻力、比气道阻力、炎性因子指标均降低,且观察组低于对照组(P＜0.05)；两组PaO2、SaO2、比气道传导率均升高,且观察组高于对照组(P＜0.05)；治疗组总有效率为94.12%(48/51),高于对照组的78.46%(40/51)(P＜0.05)；两组均未发生不良反应。结论：导痰汤加减联合常规西药能够抑制慢阻肺急性加重期患者体内炎症反应,减轻气道高反应性,纠正机体缺氧状态,改善肺通气功能,疗效显著,值得临床推广。 |
| 英文摘要: |
| Objective: Observe the clinical efficacy of combining modified Dao Tan Tang with conventional Western medicine in the treatment of acute exacerbation of chronic obstructive pulmonary disease. Method: 102 patients with acute exacerbation of chronic obstructive pulmonary disease were randomly divided into two groups using a random number table. The control group received conventional Western medicine treatment, while the treatment group combined with modified Daotan decoction. Compare the changes in traditional Chinese medicine syndrome scores, modified version of dyspnea questionnaire (mMRC score), chronic obstructive pulmonary disease assessment scale (CAT) score, blood gas indicators [arterial oxygen partial pressure (PaO2), arterial carbon dioxide partial pressure (PaCO2), oxygen saturation (SaO2)], pulmonary ventilation function indicators (airway resistance, specific airway resistance, specific airway conductivity), inflammatory factor indicators in two groups, and calculate the clinical efficacy and adverse reactions of the two groups. Result: After treatment, two groups of traditional Chinese medicine syndrome scores, mMRC score, CAT score PaCO2、the airway resistance, specific airway resistance, and inflammatory factor indicators were all reduced, and the observation group was lower than the control group (P<0.05); Two groups of PaO2、SaO2、the airway conductivity were increased in both groups, and the observation group was higher than the control group (P<0.05); The total effective rate of the treatment group was 94.12% (48/51), which was higher than the control group"s 78.46% (40/51) (P<0.05); Both groups did not experience any adverse reactions. Conclusion: The combination of modified Dao Tan Tang and conventional Western medicine can inhibit the inflammatory response in patients with acute exacerbation of chronic obstructive pulmonary disease, reduce airway hyperresponsiveness, correct the body"s hypoxic state, and improve lung ventilation function. The therapeutic effect is significant and worthy of clinical promotion. |
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