| 吴东伟.大黄牡丹汤辅助西医治疗小儿急性阑尾炎术后胃肠功能紊乱临床研究[J].浙江中西医结合杂志,2026,36(7): |
| 大黄牡丹汤辅助西医治疗小儿急性阑尾炎术后胃肠功能紊乱临床研究 |
| Clinical study on the use of Dahuang Mudan decoction as an adjunct to Western medicine in the treatment of postoperative gastrointestinal dysfunction in children with acute appendicitis |
| 投稿时间：2024-12-28 修订日期：2026-06-24 |
| DOI： |
| 中文关键词: 小儿 急性阑尾炎 阑尾炎切除术 胃肠功能紊乱 大黄牡丹汤 |
| 英文关键词:Children Acute appendicitis Appendectomy Gastrointestinal dysfunction Dahuang Mudan Soup |
| 基金项目: |
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| 中文摘要: |
| 目的? 观察针对小儿急性阑尾炎(AAP)术后胃肠功能紊乱(PGD)采用大黄牡丹汤辅助西医治疗的临床效果。方法? 采取前瞻性对照研究设计法。将本院2021年6月～2024年6月收治的72例AAP患儿纳入研究,所有患儿均于阑尾炎切除术后出现胃肠功能紊乱,随机数字表法对患儿进行分组,均分为对照组与治疗组(各36例),观察期间对照组剔除2例,治疗组剔除2例,最终2组完成研究各34例。对照组术后给予西医治疗,治疗组在西医基础上给予大黄牡丹汤辅助治疗,均连续治疗3d后判定2组临床疗效,记录术后胃肠功能恢复时间(首次排气、首次排便、肠鸣音恢复),检测患儿胃肠激素[血清胃泌素(GAS)、血浆胃动素(MTL)]、血清炎症因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平变化。结果 治疗后,治疗组总有效率94.12%高于对照组76.47%(P＜0.05)；治疗组术后首次排气时间、首次排便时间、肠鸣音恢复时间均早于对照组(P＜0.05)；治疗后,2组血清GAS、血浆MTL水平均提高(P＜0.05),治疗组上述2项指标水平较对照组提高更显著(P＜0.05)；治疗后,2组血清CRP、IL-6、TNF-α水平显著低于治疗前,治疗组上述3项指标水平较对照组降低更显著(P＜0.05)。结论? 大黄牡丹汤辅助西医治疗小儿AAP术后出现PGD患儿疗效确切,可有效促进患儿胃肠功能恢复,调节患儿胃肠激素水平,并能减轻患儿机体炎症反应。 |
| 英文摘要: |
| Objective: To observe the clinical effect of using Dahuang Mudan Decoction as an adjuvant Western medicine treatment for postoperative gastrointestinal dysfunction (PGD) in children with acute appendicitis (AAP). Methods:The adopts a prospective controlled study design. 72 children with AAP admitted to our hospital from June 2021 to June 2024 were included in the study. All children experienced gastrointestinal dysfunction after appendectomy. The children were randomly divided into a control group and a treatment group (36 cases each) using a random number table method. During the observation period, 2 cases were excluded from the control group and 2 cases were excluded from the treatment group. Finally, 34 cases were completed in each of the two groups. The control group received Western medicine treatment after surgery, while the treatment group received Dahuang Mudan Tang as an adjuvant therapy on the basis of Western medicine. The clinical efficacy of both groups was evaluated after 3 days of continuous treatment. The recovery time of gastrointestinal function after surgery (first exhaust, first defecation, and bowel sounds recovery) was recorded, and the levels of gastrointestinal kinins [serum gastrin (GAS), plasma motilin (MTL)], serum inflammatory factors [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor - α (TNF - α)] in the children were detected. Results:After treatment, the total effective rate of the treatment group was 94.12%, which was higher than the control group"s 76.47% (P<0.05); The treatment group had earlier postoperative first exhaust time, first defecation time, and bowel sound recovery time than the control group (P<0.05); After treatment, both groups showed an increase in serum GAS and plasma MTL levels (P<0.05), with the treatment group showing a more significant increase in these two indicators compared to the control group (P<0.05); After treatment, the levels of serum CRP, IL-6, and TNF - α in both groups were significantly lower than before treatment, and the levels of these three indicators in the treatment group decreased more significantly than those in the control group (P<0.05). Conclusion: The use of Dahuang Mudan Decoction as an adjunct to Western medicine is effective in treating PGD in children with AAP surgery. It can effectively promote the recovery of gastrointestinal function, regulate the levels of gastrointestinal hormones, and alleviate the inflammatory response of the child"s body. |
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