| 陈文龙.生长发育迟缓儿童垂体MRI特征与生长激素的相关性研究[J].浙江中西医结合杂志,2025,35(11): |
| 生长发育迟缓儿童垂体MRI特征与生长激素的相关性研究 |
| Characteristics of pituitary MRI examination in children with growth retardation and its correlation with growth hormone |
| 投稿时间：2025-01-18 修订日期：2025-06-03 |
| DOI： |
| 中文关键词: 生长发育迟缓 垂体 核磁共振成像 生长激素 |
| 英文关键词:Growth retardation Pituitary Magnetic resonance imaging Growth hormone |
| 基金项目:余姚市科技计划项目：编号:2022YPTO7 |
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| 中文摘要: |
| 【摘要】目的 探讨生长发育迟缓儿童垂体核磁共振成像（MRI）检查特征及与生长激素的相关性。方法 采用回顾性研究方法，选取2022年1月至2023年12月在我院治疗的生长激素异常的生长发育迟缓儿童80例作为观察组，同时选取生长激素正常的生长发育迟缓儿童50例作为对照组，比较两组患儿垂体MRI参数、生长激素（GH）激发峰值的差异。结果 观察组男童垂体体积、矢状高径、矢状前后径、冠状高径、冠状宽径和GH激发峰值均明显低于对照组（P＜0.05）；观察组女童垂体体积、矢状高径、矢状前后径、冠状高径、冠状宽径和GH激发峰值均明显低于对照组（P＜0.05）；观察组年龄≤10岁儿童垂体体积、矢状高径、矢状前后径、冠状高径、冠状宽径和GH激发峰值均明显低于对照组年龄≤10岁儿童（P＜0.05）；观察组年龄＞10岁儿童垂体体积、矢状高径、矢状前后径、冠状高径、冠状宽径和GH激发峰值均明显低于对照组年龄＞10岁儿童（P＜0.05）；生长发育迟缓儿童垂体矢状高径、冠状高径与GH激发峰值呈正相关（P＜0.05）。结论 生长激素异常的生长发育迟缓儿童垂体MRI参数及GH激发峰值明显降低，MRI参数矢状高径、冠状高径与GH激发峰值呈正相关。 |
| 英文摘要: |
| Objective: To explore the characteristics of pituitary magnetic resonance imaging (MRI) in children with growth and development delay and its correlation with growth hormone. Methods: Retrospective research method were used, 80 children with abnormal growth hormone and growth retardation treated in our hospital from January 2022 to December 2023 were selected as the observation group, while 50 children with normal growth hormone and growth retardation were selected as the control group. The differences in pituitary MRI parameters and growth hormone (GH) peak values between the two groups were compared. Results: The pituitary physical examination, sagittal height diameter, sagittal anterior posterior diameter, coronal height diameter, coronal width diameter, and GH stimulation peak of the observation group boys were significantly lower than those of the control group (P<0.05). The pituitary physical examination, sagittal height, sagittal anterior posterior diameter, coronal height, coronal width, and GH stimulation peak of the observation group of girls were significantly lower than those of the control group (P<0.05). The pituitary physical examination, sagittal height diameter, sagittal anterior posterior diameter, coronal height diameter, coronal width diameter, and GH stimulation peak of children aged ≤ 10 years in the observation group were significantly lower than those of children aged ≤ 10 years in the control group (P<0.05). The pituitary physical examination, sagittal height diameter, sagittal anterior posterior diameter, coronal height diameter, coronal width diameter, and GH stimulation peak of children aged over 10 years in the observation group were significantly lower than those of children aged over 10 years in the control group (P<0.05). The sagittal and coronal diameters of the pituitary gland in children with growth and development delay are positively correlated with the peak of GH stimulation (P<0.05). Conclusion: The MRI parameters and GH stimulation peak of pituitary gland in children with abnormal growth hormone? and growth retardationare significantly reduced, and the MRI parameters of sagittal and coronal diameters are positively correlated with GH stimulation peak. |
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