| 陈正胜,郑青秀,陈后良,钟金梨,包玉玲,陈小宝.补肺汤联合血府逐瘀汤改善非小细胞肺癌血液高凝状态的临床观察[J].浙江中西医结合杂志,2025,35(12): |
| 补肺汤联合血府逐瘀汤改善非小细胞肺癌血液高凝状态的临床观察 |
| Effects of treatment with tonifying lung soup combined with haematopoietic blood stasis-expelling soup on the hypercoagulable state of blood in patients with non-small cell lung cancer |
| 投稿时间：2025-02-07 修订日期：2025-07-22 |
| DOI： |
| 中文关键词: 补肺汤 血府逐瘀汤 非小细胞肺癌 血液高凝状态 生活质量 |
| 英文关键词:Lung tonic soup Haifu yuyu tang Non-small cell lung cancer Hypercoagulable state of blood Quality of life |
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| 中文摘要: |
| 目的 观察补肺汤合血府逐瘀汤治疗对非小细胞肺癌(NSCLC)患者血液高凝状态的影响。方法 收集2021年5月～2024年10月来我院进行就诊且符合纳入排除标准的110例NSCLC患者,按数字表法随机分为综合组(55例)和对症组(55例)。对症组给予对症支持治疗,综合组在对症组基础上加用补肺汤合血府逐瘀汤治疗,两组均连续治疗8周。统计两组临床总有效率,比较两组治疗前后凝血功能、纤溶活性指标、血液流变学指标、中医症状评分、生活质量评分变化。结果 综合组总有效率为69.09%与对症组的61.82%比较,无差异(P>0.05)。治疗前,两组凝血功能比较无差异(P>0.05)。两组治疗后活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、组织纤溶酶原激活物(t-PA)、凝血酶时间(TT)均较治疗前升高,且综合组治疗后高于对症组(P<0.05)。两组治疗后纤维蛋白原(FIB)、纤溶酶原激活物抑制剂1(PAI-1)、D二聚体 (D-D)均较治疗前降低,且综合组治疗后低于对症组(P<0.05)。治疗前,两组血液流变学指标比较无差异(P>0.05)。两组治疗后全血高/低切黏度、血浆黏度、小板聚集率均较治疗前降低,且综合组治疗后低于对症组(P<0.05)。治疗前,两组中医症状评分、生活质量评分比较无差异(P>0.05)。两组治疗后中医症状评分均较治疗前降低,且综合组治疗后低于对症组(P<0.05)。两组治疗后生活质量评分均较治疗前升高,且综合组治疗后高于对症组(P<0.05)。结论 补肺汤合血府逐瘀汤治疗NSCLC可改善血液高凝状态,减轻症状,提高生活质量。 |
| 英文摘要: |
| Objective To observe the effect of Lung Tonifying Tang combined with Haifu Yuyu Tang treatment on the hypercoagulable state of blood in patients with non-small cell lung cancer (NSCLC).Methods One hundred and ten NSCLC patients who came to our hospital from May 2021 to October 2024 and met the inclusion and exclusion criteria were collected and randomly divided into the comprehensive group (55 cases) and the symptomatic group (55 cases) according to the numerical table method. The symptomatic group was given symptomatic supportive treatment, and the comprehensive group was treated with Lung Tonic Tang and Haifu Yuyu Tang on the basis of the symptomatic group, and both groups were treated continuously for 8 weeks. The total clinical efficiency of the two groups was counted, and the changes in coagulation function, fibrinolytic activity indexes, blood rheological indexes, TCM symptom scores and quality of life scores were compared between the two groups before and after treatment.Results There was no difference in the total effective rate of 69.09% in the integrated group compared with 61.82% in the symptomatic group (P>0.05). Before treatment, there was no difference in the comparison of coagulation function between the two groups (P>0.05). Activated partial thromboplastin time (APTT), tissue plasminogen activator (t-PA), prothrombin time (PT), and thrombin time (TT) were higher in both groups after treatment compared with that before treatment, and were higher in the combined group than in the symptomatic group after treatment (P<0.05). Fibrinogen (FIB), fibrinogen activator inhibitor 1 (PAI-1), and D-dimer (D-D) were lower in both groups after treatment than before treatment, and were lower in the integrated group than in the symptomatic group after treatment (P<0.05). Before treatment, there was no difference in blood rheological indexes between the two groups (P>0.05). Whole blood high/low cut viscosity, plasma viscosity, and platelet aggregation rate were lower in both groups after treatment than before treatment, and the comprehensive group was lower than the symptomatic group after treatment (P<0.05). Before treatment, there was no difference in the comparison of TCM symptom scores and quality of life scores between the two groups (P>0.05). The quality of life scores of both groups were higher after treatment than before treatment, and the comprehensive group was higher than the symptomatic group after treatment (P<0.05). The TCM symptom scores of both groups were lower after treatment than before treatment, and the comprehensive group was lower than the symptomatic group after treatment (P<0.05).Conclusion Lung tonic soup combined with haematopoietic blood-stasis-expelling soup in the treatment of NSCLC improves the hypercoagulable state of blood, reduces symptoms, and improves the quality of life. |
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