| 徐永冬,陈奇凯,竹汉钦,许琳琳,龚心怡,董雷.中医药干预变应性鼻炎相关信号通路的研究进展[J].浙江中西医结合杂志,2025,35(9): |
| 中医药干预变应性鼻炎相关信号通路的研究进展 |
| Research progress of traditional Chinese medicine in intervening the signaling pathway related to allergic rhinitis |
| 投稿时间：2025-02-10 修订日期：2025-05-04 |
| DOI： |
| 中文关键词: 变应性鼻炎 信号通路 中医药 作用机制 |
| 英文关键词:allergic rhinitis signaling pathway traditional Chinese medicine mechanism of action |
| 基金项目: |
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| 中文摘要: |
| 变应性鼻炎(Allergic rhinitis,AR)是一种常见的变态反应性疾病,好发于儿童及青少年。西医治疗虽然能够短时间缓解患者的症状,但不良反应较多,疾病的复发率也较高。近年来,随着对中医药的不断研究,中医中药在变应性鼻炎的治疗中显示出了独特的优势。大量研究表明单味中药、中药提取物、中药复方及中医独特的外治法可以通过多种信号通路干预变应性鼻炎。本文通过查阅近几年国内外的文献进行总结,发现TLR/NF?κB、JAK/STAT、PI3K/AKT、IL-33/ST2、Notch1-Jagged1等信号通路与鼻炎有着紧密的联系,并且将中医药干预这些信号通路而取得的疗效进行总结分析,旨在为中医药防治鼻炎提供新的思路及探索中医药新的作用靶点。 |
| 英文摘要: |
| Allergic rhinitis (AR) is a common allergic disease that frequently occurs in children and adolescents. Although Western medicine can relieve the symptoms of patients in the short term, it has many adverse reactions and a high recurrence rate. In recent years, with the continuous research on traditional Chinese medicine (TCM), TCM has shown unique advantages in the treatment of allergic rhinitis. A large number of studies have shown that single herbs, herbal extracts, herbal formulas, and unique external treatment methods of TCM can intervene in allergic rhinitis through multiple signaling pathways. This article summarizes the literature at home and abroad in recent years and finds that TLR/NF-κB, JAK/STAT, PI3K/AKT, IL-33/ST2, Notch1-Jagged1 and other signaling pathways are closely related to rhinitis. The therapeutic effects of TCM intervention in these signaling pathways are summarized and analyzed, aiming to provide new ideas for the prevention and treatment of rhinitis with TCM and explore new targets of TCM. |
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