| 魏满霞,李东豫,占长玉.除湿解毒汤加减结合西医治疗HR-HPV感染高级别上皮内瘤变（湿热蕴毒型）患者的作用探讨[J].浙江中西医结合杂志,2025,35(9): |
| 除湿解毒汤加减结合西医治疗HR-HPV感染高级别上皮内瘤变（湿热蕴毒型）患者的作用探讨 |
|
| 投稿时间：2025-02-14 修订日期：2025-05-07 |
| DOI： |
| 中文关键词: 高危型人乳头瘤病毒 除湿解毒汤 高级别上皮内瘤变 西医 湿热蕴毒型 |
| 英文关键词:High-risk human papilloma virus Chushi Jiedu Decoction High grade cervical intraepithelial neoplasia Western medicine Damp-heat accumulation type |
| 基金项目: |
|
| 摘要点击次数: 93 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的:探讨除湿解毒汤加减结合西医治疗湿热蕴毒型高危型人乳头瘤病毒(HR-HPV)感染高级别宫颈上皮内瘤变(HGCIN)患者的作用。方法:选取医院2022年1月~2023年6月收治的150例湿热蕴毒型HR-HPV感染HGCIN患者为研究对象,采取摸球法随机分为西医组、联合中医组,每组75例。西医组常规采用宫颈环形电切刀+重组人干扰素阴道泡腾胶囊治疗,联合中医组则在西医组基础上采取除湿解毒汤加减治疗,连续治疗6周。于治疗前后记录2组中医症状评分；统计治疗后的HR-HPV转阴率；评估2组临床疗效；采集治疗前后静脉血,流式细胞仪检测T淋巴细胞亚群指标；统计2组不良反应发生率。结果:治疗后2组中医症状评分降低(P＜0.05),其中联合中医组＜西医组(P＜0.05)；HR-HPV转阴率:联合中医组＞西医组(P＜0.05),且联合中医组的转阴情况分布与西医组相比差异有统计学意义(P＜0.05)；总有效率:联合中医组＞西医组(P＜0.05),联合中医组临床疗效与西医组相比差异有统计学意义(P＜0.05)；治疗后2组CD3+、CD4+、CD4+/CD8+升高(P＜0.05),且联合中医组的CD3+、CD4+、CD4+/CD8+高于西医组(P＜0.05)；2组不良反应发生率基本一致(P＞0.05)。结论:除湿解毒汤加减结合西医治疗湿热蕴毒型HR-HPV感染HGCIN的效果显著,可改善中医症状评分,促进HR-HPV转阴,增强T细胞免疫功能,安全性高。 |
| 英文摘要: |
| Objective: To explore the role of modified Chushi Jiedu Decoction combined with western medicine in treating patients with high-grade cervical intraepithelial neoplasia (HGCIN) infected by high-risk human papillomavirus (HR-HPV) with damp-heat accumulation. Methods: 150 cases of HGCIN infected by HR-HPV with damp-heat accumulation in our hospital from January 2022 to June 2023 were selected as the research object, and were randomly divided into western medicine group and combined Chinese medicine group by touching the ball, with 75 cases in each group. The western medicine group was treated with circular electrosurgical excision procedure and recombinant human interferon vaginal effervescent capsule, while the combined Chinese medicine group was treated with modified Chushi Jiedu decoction on the basis of the western medicine group for 6 weeks. Before and after treatment, the TCM symptom scores of the two groups were recorded. The negative rates of HR-HPV after treatment were counted. The clinical efficacy was evaluated in the two groups. Venous blood was collected before and after treatment, and T lymphocyte subsets were detected by flow cytometry. The incidences of adverse reactions in the two groups were counted. Results:After treatment, the scores of TCM symptoms in the two groups decreased (P < 0.05), among them, the United Chinese Medicine Group < Western Medicine Group (P < 0.05). The negative rate of HR-HPV: combined Chinese medicine group > western medicine group. (P < 0.05), and the distribution of negative conversion in the combined Chinese medicine group was significantly different from that in the western medicine group (P < 0.05). Total effective rate: combined Chinese medicine group > western medicine group (P < 0.05), The clinical efficacy of the combined Chinese medicine group was significantly different from that of the western medicine group (P < 0.05). After treatment, CD3+, CD4+ and CD4+/CD8+ in the two groups increased (P < 0.05), and the CD3+, CD4+ and CD4+/CD8+ in the combined Chinese medicine group were higher than those in the western medicine group (P < 0.05). The incidence of adverse reactions in the two groups was basically the same (P > 0.05). Conclusion: Modified Chushi Jiedu Decoction combined with western medicine has a significant effect on treating HGCIN infected with damp-heat toxic type HR-HPV, which can improve TCM symptom score, promote the negative conversion of HR-HPV, and enhance T cell immune function with high safety. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
