| 周蜜.尖锐湿疣患者血清IL-35、sPD-1表达及其与5-氨基酮戊酸光动力疗法治疗后复发的相关性[J].浙江中西医结合杂志,2026,36(3): |
| 尖锐湿疣患者血清IL-35、sPD-1表达及其与5-氨基酮戊酸光动力疗法治疗后复发的相关性 |
| The expression of serum IL-35 and sPD-1 in patients with condyloma acuminatum and their correlation with recurrence after 5-aminolevulinic acid photodynamic therapy |
| 投稿时间：2025-02-18 修订日期：2026-01-15 |
| DOI： |
| 中文关键词: 白介素-35 可溶性程序性细胞死亡蛋白-1 5-氨基酮戊酸光动力疗法 尖锐湿疣 复发 相关性 |
| 英文关键词:Interleukin-35 Soluble programmed cell death protein-1 5-aminolevulinic acid photodynamic therapy Condyloma acuminatum Recurrence Correlation |
| 基金项目:浙江省中医药科技计划项目 |
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| 中文摘要: |
| 目的:研究血清白介素-35(IL-35)、可溶性程序性细胞死亡蛋白-1(sPD-1)在经5-氨基酮戊酸光动力疗法(5-ALA-PDT)治疗的尖锐湿疣患者中的表达情况,并分析两者与治疗后复发的相关性。方法:选取本院于2022年1月-2024年1月均进行5-氨基酮戊酸光动力治疗的尖锐湿疣患者80例,根据治疗后随访情况分为复发组(n=25)和未复发组(n=55),经ELISA检测后,比较两组血清IL-35、sPD-1水平及一般临床资料情况,采用Spearman等级相关分析血清IL-35、sPD-1与患者治疗后复发的相关性,Logistic回归分析患者治疗后复发的影响因素,绘制受试者工作特征(ROC)曲线分析血清IL-35、sPD-1对患者治疗后复发的预测价值。结果:复发组人乳头瘤病毒感染高危型占比显著高于未复发组(P＜0.05)；与未复发组相比,复发组的血清IL-35、sPD-1水平均显著升高(P＜0.05)；血清IL-35、sPD-1与患者治疗后复发均呈正相关(r=0.496,0.521,P＜0.05)；ROC曲线显示血清IL-35、sPD-1联合预测患者治疗后复发的AUC显著高于IL-35(Z=2.109,P=0.035)、sPD-1(Z=2.611,P=0.009)单独预测；人乳头瘤病毒感染高危、IL-35、sPD-1水平升高均为影响患者治疗后复发的危险因素(P＜0.05)。结论:血清IL-35、sPD-1在5-ALA-PDT治疗后复发的尖锐湿疣患者中水平增加,与患者治疗后复发具有一定相关性。 |
| 英文摘要: |
| Objective: To investigate the expression of serum interleukin-35 (IL-35) and soluble programmed cell death protein-1 (sPD-1) in patients with condyloma acuminatum treated with 5-aminolevulinic acid photodynamic therapy (5-ALA-PDT), and to analyze their correlation with recurrence after treatment. Methods: From January 2022 to January 2024, 80 patients with condyloma acuminatum who underwent photodynamic therapy with 5-aminolevulinic acid in our hospital were collected and assigned into recurrence group (n=25) and non recurrence group (n=55) based on follow-up after treatment. After ELISA detection, the serum IL-35, sPD-1 levels, and general clinical data of the two groups were compared. Spearman rank correlation was used to analyze the correlation between serum IL-35, sPD-1, and recurrence after treatment in patients. Logistic regression was used to analyze the influencing factors of recurrence in patients after treatment. In addition, receiver operating characteristic (ROC) curves were plotted to analyze the predictive value of serum IL-35 and sPD-1 for recurrence after treatment. Results: The proportion of high-risk human papillomavirus infection in recurrence group was prominently higher than non recurrence group (P<0.05). Compared with non recurrence group, the serum IL-35 and sPD-1 in recurrence group were prominently higher (P<0.05). Serum IL-35 and sPD-1 were positively correlated with recurrence after treatment (r=0.496, 0.521, P<0.05). ROC curve showed that the AUC of joint of serum IL-35 and sPD-1 in predicting recurrence after treatment was prominently higher than that of IL-35 alone (Z=2.109, P=0.035) and sPD-1 alone (Z=2.611, P=0.009). High risk human papillomavirus infection and elevated levels of IL-35 and sPD-1 were all risk factors for postoperative recurrence in patients (P<0.05). Conclusion: Serum IL-35 and sPD-1 increase in patients with recurrent condyloma acuminatum after 5-ALA-PDT treatment, and are correlated with recurrence after treatment. |
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