| 陈佳巧,宋伟杰,王永武,陈超,柳叶春,陶冶.西帕依固龈液治疗妊娠期龈炎的临床疗效研究[J].浙江中西医结合杂志,2026,36(3): |
| 西帕依固龈液治疗妊娠期龈炎的临床疗效研究 |
| Xipayi Mouth Rinse for Pregnancy Gingivitis: A Clinical Efficacy Trial |
| 投稿时间：2025-03-03 修订日期：2025-05-24 |
| DOI： |
| 中文关键词: 西帕依固龈液 妊娠期龈炎 西吡氯铵含漱液 |
| 英文关键词:Xipayi mouth rinse, pregnancy-associated gingivitis cetylpyridinium chloride mouthwash |
| 基金项目:杭州市生物医药和健康产业发展扶持科技专项项目(第八期)(No:2022WJC182) |
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| 中文摘要: |
| 目的 探究西帕依固龈液对妊娠期妇女龈炎的治疗效果,对比其与现有治疗方案在疗效和不良反应中的区别。方法 选取2023年1月至2023年12月我中心收治的35例妊娠期龈炎患者,按照随机数字表法,分为观察组和对照组。观察组(n=20)给予西帕依固龈液含漱治疗；对照组(n=15)给予西吡氯铵含漱液含漱治疗。对比两组患者治疗前后的口腔卫生指数(OHI-S)、牙菌斑指数(PLI)、牙龈指数(GI)、龈沟出血指数(SBI）与牙龈出血指数(GBI)和血液炎症指标,并记录用药不良反应情况。结果 两组患者治疗后牙周卫生指数均明显改善,其中西帕依固龈液对于减少牙石沉积 、龈沟出血（P <0.05）的改善情况优于西吡氯胺含漱液。观察组患者治疗前血液白细胞计数(WBC)与中性粒细胞百分比(NE%)分别为9.19±1.64×109 /L和70.96±7.09%,而治疗后为9.54±2.16×109 /L和71.31±7.71%,无显著改变。观察组与对照组在改善血液炎症指标方面无显著差异(P >0.05)。对照组患者治疗过程中报告2例患者出现味觉减退(2/15,13.3%),而观察组患者未报告过敏、味觉减退、食欲不振等不良反应。结论 西帕依固龈液对妊娠期龈炎患者具有良好的治疗效果,其疗效优于目前常用的西吡氯铵含漱液,且不良反应发生率更低，其在妊娠期妇女口腔疾病的治疗中具有广泛前景。 |
| 英文摘要: |
| Objective To investigate the therapeutic efficacy of Xipayi mouth rinse in the treatment of gingivitis in pregnant women, and to compare its efficacy and adverse reactions with existing treatment regimens.
Methods A total of 35 pregnant patients with gingivitis admitted to our center from January 2023 to December 2023 were enrolled. Using the random number table method, they were divided into an observation group and a control group. The observation group (n=20) received gargle treatment with Xipayi mouth rinse, while the control group (n=15) received gargle treatment with cetylpyridinium chloride mouthwash. The Oral Hygiene Index-Simplified (OHI-S), Plaque Index (PLI), Gingival Index (GI), Sulcus Bleeding Index (SBI), Gingival Bleeding Index (GBI), and blood inflammatory markers were compared between the two groups before and after treatment. Adverse reactions during medication were also recorded.
Results Periodontal hygiene indices were significantly improved in both groups after treatment. Notably, Xipayi mouth rinse showed superior efficacy in reducing calculus deposition and sulcus bleeding (P < 0.05) compared to cetylpyridinium chloride mouthwash. In the observation group, the pre-treatment white blood cell count (WBC) and neutrophil percentage (NE%) were 9.19±1.64×10?/L and 70.96±7.09%, respectively, which showed no significant changes post-treatment (9.54±2.16×10?/L and 71.31±7.71%, respectively). No significant differences were observed between the two groups in terms of improving blood inflammatory markers (P > 0.05). In the control group, 2 cases (2/15, 13.3%) reported hypogeusia during treatment, whereas no adverse reactions such as allergy, hypogeusia, or anorexia were reported in the observation group.
Conclusion Xipayi mouth rinse demonstrates favorable therapeutic efficacy in pregnant patients with gingivitis. Its efficacy is superior to the commonly used cetylpyridinium chloride mouthwash, with a lower incidence of adverse reactions, indicating broad prospects for its application in the treatment of oral diseases in pregnant women. |
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