| 曹占兴,黄转平.补气活血益肾方联合依帕司他片对老年早期糖尿病肾病患者NLRP3炎症小体表达的影响[J].浙江中西医结合杂志,2026,36(1): |
| 补气活血益肾方联合依帕司他片对老年早期糖尿病肾病患者NLRP3炎症小体表达的影响 |
| Effect of Buqi Huoxue Yishen Recipe and Epalrestat Tablets on the Expression of NLRP3 Inflammatory Bodies in Elderly Patients with Early diabetic Nephropathy |
| 投稿时间：2025-03-19 修订日期：2025-06-12 |
| DOI： |
| 中文关键词: 早期糖尿病肾病 老年人 补气活血益肾方 依帕司他片 NOD样受体热蛋白结构域相关蛋白3 |
| 英文关键词:Early diabetic nephropathy Elderly Buqi Huoxue Yishen Recipe Epalrestat tablets NOD like receptor thermal protein domain associated protein 3 |
| 基金项目:杭州市医药卫生科技项目（编号B20241920） |
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| 中文摘要: |
| 目的：探讨补气活血益肾方联合依帕司他片对老年早期糖尿病肾病(EDN)患者NOD样受体热蛋白结构域相关蛋白3(NLRP3)炎症小体表达的影响。方法：选择2024年1月至2024年12月至本院就诊的296例EDN患者为研究对象,按照就诊先后次序由前及后顺序进行编码,编码为奇数进入对照组,偶数进入研究组,各148例,在常规干预基础上,给予对照组依帕司他片,研究组在对照组基础上给予补气活血益肾方口服,连续治疗4周后评估治疗效果,包括中医证候积分、NLRP3炎症小体相关指标、血管内皮功能及药物安全性。结果：治疗后,两组中医证候积分较治疗前下降,且研究组下降较对照组更显著(P＜0.05)。治疗后,两组NLRP3、胱天蛋白酶1(caspase-1)蛋白、白细胞介素(IL)-1β、IL-18较治疗前下降,且研究组低于对照组(P＜0.05)。治疗后,两组内皮素-1(ET-1)、髓样细胞触发受体样转录因子-1(sTLT-1)较治疗前下降,且研究组低于对照组；两组降钙素基因相关肽(CGRP)水平提升,且研究组高于对照组(P＜0.05)。两组不良反应发生率比较,差异无统计学意义(P＞0.05)。结论：补气活血益肾方联合依帕司他片治疗老年EDN患者,可降低中医证候积分、改善NLRP3炎症小体表达和血管内皮功能,且不会增加药物不良反应。 |
| 英文摘要: |
| Objective: To investigate the effect of Buqi Huoxue Yishen recipe combined with epalrestat tablet on the expression of inflammatory corpuscles of NOD like receptor heat protein domain associated protein 3 (NLRP3) in elderly patients with early diabetic nephropathy (EDN). Method: 296 patients with EDN who visited our hospital from January 2024 to December 2024 were selected as the research subjects. They were coded in order of their visits, from front to back, with odd numbers entering the control group and even numbers entering the study group, with 148 patients in each group. On the basis of routine intervention, the control group was given epalrestat tablets, while the study group was given Buqi Huoxue Yishen Recipe orally on the basis of the control group. After 4 weeks of continuous treatment, the treatment effect was evaluated, including traditional Chinese medicine syndrome score, NLRP3 inflammasome related indicators, vascular endothelial function, and drug safety. Result: After treatment, the scores of traditional Chinese medicine syndrome in both groups decreased compared to before treatment, and the decrease in the study group was more significant than that in the control group (P<0.05). After treatment, the levels of NLRP3, caspase-1 protein, interleukin-1 β, and IL-18 in both groups decreased compared to before treatment, and the study group was lower than the control group (P<0.05). After treatment, endothelin-1 (ET-1) and myeloid cell triggered receptor like transcription factor-1 (sTLT-1) in both groups decreased compared to before treatment, and the study group was lower than the control group. The levels of calcitonin gene-related peptide (CGRP) were elevated in both groups, and the study group was higher than the control group (P<0.05). There was no statistical significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The combination of Buqi Huoxue Yishen Recipe and epalrestat tablets can reduce traditional Chinese medicine syndrome scores, improve NLRP3 inflammasome expression and endothelial function in elderly patients with EDN, without increasing adverse drug reactions. |
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