| 唐小玉,余艳妹,徐笑燕.清心培土方联合他克莫司软膏治疗儿童特应性皮炎临床观察[J].浙江中西医结合杂志,2026,36(1): |
| 清心培土方联合他克莫司软膏治疗儿童特应性皮炎临床观察 |
| Clinical observation of Qingxin peitu prescription combined with tacrolimus ointment in the treatment of atopic dermatitis in childrenTANG Xiaoyu,YU Yanmei,XU Xiaoyan,Chun"an County Hospital of Chinese Medicine?,311700 |
| 投稿时间：2025-03-20 修订日期：2025-10-02 |
| DOI： |
| 中文关键词: 清心培土方 他克莫司软膏 特应性皮炎 皮肤屏障 肠道菌群 |
| 英文关键词:Qingxin peitu prescription Tacrolimus ointment Atopic dermatitis Skin barrier Intestinal flora |
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| 中文摘要: |
| 目的：探讨清心培土方联合他克莫司软膏治疗儿童特应性皮炎临床疗效。方法：选择于我院就诊的特应性皮炎患儿92例,采用简单化分组方法随机分为观察组与对照组各46例,对照组给予他克莫司软膏治疗,观察组在其基础上给予清心培土方治疗。观察两组患儿治疗后中医证候评分,相关量表评分[特应性皮炎积分指数(SCORAD)评分、儿童皮肤病生活质量指数问卷(CDLQI)评分],皮肤屏障功能指标,实验室指标(外周血嗜酸性粒细胞、血清总免疫球蛋白E水平),肠道菌群及临床疗效。结果：两组治疗后中医证候评分、SCORAD评分、CDLQI评分、外周血嗜酸性粒细胞计数、血清总免疫球蛋白E水平均较治疗前降低,且观察组低于对照组(P＜0.05)。两组治疗后经皮水分丢失量、肠球菌数量、大肠杆菌数量均较治疗前降低,两组治疗后表皮水分含量、表皮油脂含量、双歧杆菌、乳酸杆菌数量均较治疗前升高,且观察组改善程度优于对照组(P＜0.05)。观察组治疗后总有效率为93.48%高于对照组82.61%(P＜0.05)。结论：清心培土方联合他克莫司软膏治疗儿童特应性皮炎临床疗效显著。 |
| 英文摘要: |
| Objective: To explore the clinical effect of qingxin peitu prescription combined with tacrolimus ointment in the treatment of atopic dermatitis in children. Methods: 92 children with atopic dermatitis treated in our hospital. The control group was treated with tacrolimus ointment, and the observation group was treated with qingxin peitu prescription on the basis of tacrolimus ointment. TCM syndrome scores, relevant scale scores [SCORAD score, CDLQI score], skin barrier function indexes, laboratory indexes (peripheral blood eosinophils, serum total immunoglobulin E levels), intestinal flora and clinical efficacy of the two groups were observed after treatment. Results: TCM syndrome score, SCORAD score, CDLQI score, peripheral blood eosinophilia count and serum total immunoglobulin E level were all decreased after treatment in both groups. the amount of transdermal water loss, the number of enterococcus and the number of Escherichia coli in both groups were lower than before treatment, and the amount of epidermal water content, epidermal oil content, bifidobacterium and lactobacillus in both groups were higher than before treatment (P < 0.05). The observe group effective rate was 93.48% higher control group 82.61%(P < 0.05). Conclusion: Qingxin peitu prescription combined with tacrolimus ointment has significant clinical effect on children with atopic dermatitis. |
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