| 阮正英,范广民,曹学全,蔡小波,应成龙,罗斌.UBIAD1、EEF1B2和 MMRN1在胃腺癌临床病理特征中的作用[J].浙江中西医结合杂志,2026,36(1): |
| UBIAD1、EEF1B2和 MMRN1在胃腺癌临床病理特征中的作用 |
| Roles of UBIAD1, EEF1B2, and MMRN1 expression in the clinical and pathological characteristics of gastric adenocarcinoma |
| 投稿时间：2025-03-26 修订日期：2025-08-26 |
| DOI： |
| 中文关键词: 胃腺癌 UBIAD1 EEF1B2 MMRN1 病理特征 |
| 英文关键词:Gastric adenocarcinoma UBIAD1 EEF1B2 MMRN1 Pathological features |
| 基金项目:温岭市科研基金资助项目(2023S00179) |
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| 中文摘要: |
| 目的 探过含UbiA异戊二烯基转移酶结构域1(UBIAD1)、真核翻译延伸因子1β2(EEF1B2)和多聚蛋白1(MMRN1)表达在胃腺癌临床病理特征中的作用。方法 选取127例胃腺癌组织(胃腺癌组)及其癌旁正常组织(对照组),免疫组化法检测两组UBIAD1、EEF1B2和 MMRN1的表达水平,并分析它们与胃腺癌患者临床病理特征的关系。结果 胃腺癌组EEF1B2和 MMRN1表达的阳性率和阳性强度均显著高于对照组(P<0.05或P<0.01)；胃腺癌组 UBIAD1表达的阳性强度显著高于对照组(P<0.01)。胃腺癌组UBIAD1表达的阳性率在肿块最大径≥5CM、低分化、临床分期为Ⅲ-Ⅳ期、伴有淋巴结转移显著增高 (P<0.01或P<0.05)；胃腺癌组UBIAD1表达的阳性强度在低分化、浸润深度在固有肌层及以外显著增高 (均P< 0.01)。胃腺癌组EEF1B2表达的阳性率在低分化、伴有淋巴结转移显著增高 (P<0.05、或P<0.01),胃腺癌组EEF1B2表达的阳性强度在临床分期为Ⅲ-Ⅳ期、伴有淋巴结转移显著增高 (均P<0.01)。胃腺癌组MMRN1表达的阳性率在浸润深度在固有肌层及以外、伴有淋巴结转移显著增高 (P<0.05或P<0.01),胃腺癌组MMRN1表达的阳性强度在肿块最大径≥5CM、低分化、临床分期为Ⅲ-Ⅳ期、浸润深度在固有肌层及以外、伴有淋巴结转移显著增高 (P<0.05或P<0.01)。胃腺癌组EEF1B2阳性表达强度分别与UBIAD1和 MMRN1表达的阳性强度阳性表达强度呈显著正相关(分别为r= 0.256,P<0.01；r=0.220,P<0.01)。结论 UBIAD1、EEF1B2和 MMRN1在胃腺癌中表达水平增加,并与胃腺癌的不良临床病理特征有关,高表达的UBIAD1、 |
| 英文摘要: |
| Objective To investigate the roles of UbiA prenyltransferase domain-containing protein 1 (UBIAD1), eukaryotic translation elongation factor 1-beta (EEF1B2),and multimerin 1 (MMRN1) expression in the clinical and pathological characteristics of gastric adenocarcinoma. Methods 127 cases of gastric adenocarcinoma tissues diagnosed by postoperative pathology from January 2019 to January 2024 was established. Gastric adenocarcinoma tissues (gastric adenocarcinoma group) and their adjacent normal tissues (control group) were taken by immunohistochemistry method to observe the expression levels of UBIAD1, EEF1B2, and MMRN1, and the relationship between the expression levels of UBIAD1, EEF1B2, and MMRN1 with clinical and pathological characteristics of gastric adenocarcinoma. Results The positive rate and intensity of EEF1B2 and MMRN1 expression in gastric adenocarcinoma group were significantly higher than those in control group(P<0.05 or P<0.01). The positive intensity of UBIAD1 expression in gastric adenocarcinoma group was significantly higher than that in control group(P<0.01). The positive rate of UBIAD1 expression in gastric adenocarcinoma group was significantly increased when the maximum diameter of the tumor was ≥ 5CM, poorly differentiated, clinically staged as stage III-IV, and accompanied by lymph node metastasis(P<0.01 or P<0.05). The positive intensity of UBIAD1 expression in gastric adenocarcinoma group was significantly increased in low differentiation, infiltration depth in the intrinsic muscle layer or beyond (all P< 0.01). The positive rate of EEF1B2 expression in gastric adenocarcinoma group was significantly increased in poorly differentiated patients, and with lymph node metastasis(P<0.01 or P<0.05). The positive intensity of EEF1B2 expression in gastric adenocarcinoma group was significantly increased in clinical stage III-IV ,and with lymph node metastasis(all P< 0.01). The positive rate of MMRN1 expression in gastric adenocarcinoma group was significantly increased when the infiltration depth was in the intrinsic muscle layer and beyond, and with lymph node metastasis(P<0.05 or P<0.01). The positive intensity of MMRN1 expression in gastric adenocarcinoma group was significantly increased in tumors with a maximum diameter of ≥ 5CM, low differentiation, clinical stage of III-IV, invasion depth in the intrinsic muscle layer or beyond, and with lymph node metastasis(P<0.05 or P<0.01). There were significantly positively correlated of the positive expression intensity between EEF1B2 and UBIAD1, or EEF1B2 and MMRN1 in gastric adenocarcinoma group(r=0.256, P<0.01),or r=0.220,P<0.01, respectively). Conclusion The expression levels of UBIAD1、EEF1B2 and MMRN1 were increased in gastric adenocarcinoma, and associated with adverse clinical pathological features of gastric adenocarcinoma. The elevate expression of UBIAD1、EEF1B2 and MMRN1 may play a promoting or inhibiting roles in cancer development and progress, and act as biomarkers for poor prognosis. |
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