| 王育育,龚福英,胡蔚,薛娜.温针灸联合伏诺拉生干预胃食管反流病寒证的临床疗效研究[J].浙江中西医结合杂志,2026,36(1): |
| 温针灸联合伏诺拉生干预胃食管反流病寒证的临床疗效研究 |
| A Clinical Study on the Efficacy of Warm Acupuncture Combined with Vonoprazan in the Treatment of Cold Syndrome in Gastroesophageal Reflux Disease |
| 投稿时间：2025-04-02 修订日期：2025-08-09 |
| DOI： |
| 中文关键词: 温针灸 伏诺拉生 胃食管反流病 |
| 英文关键词:warm acupuncture Vonoprazan gastroesophageal reflux disease |
| 基金项目:平湖市科技计划项目（平科技[2024]9号社发类26）；第二批嘉兴市中医药重点学科建设计划项目（嘉卫[2023]65号-34） |
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| 中文摘要: |
| 目的:评估中医温针灸疗法联合伏诺拉生对胃食管反流病(GERD)的协同治疗效果。方法:本研究纳入本院2024年1月至2025年1月收治的GERD患者80例,随机分为对照组(40例)与治疗组(40例)。基础治疗方案为口服富马酸伏诺拉生片(20mg qd),疗程4周。治疗组在此基础上加用温针灸,治疗频次为每周3次,总疗程相同。采用中医证候积分、反流性疾病问卷(RDQ)与胃食管反流病问卷(GerdQ)标准化测评、内镜下食管炎症分级评估(LA分级标准)以及中医证候改善有效率进行疗效评估。结果:治疗4周后,两组患者在中医证候积分(P=0.002)和量表评分(RDQ:P=0.000;GerdQ:P=0.000)方面的改善均具有统计学意义,其中治疗组总有效率(100.0%)优于对照组(90.0%)(P=0.012)。内镜评估显示,治疗组炎症缓解有效率(97.5%)较对照组(65.0%)具有显著优势(P=0.001)。结论:温针灸与伏诺拉生的联合治疗方案在改善GERD患者临床症状、生活质量及病理学改变方面具有协同增效作用,其临床应用价值显著,建议作为优化治疗方案进行推广。 |
| 英文摘要: |
| Objective: To evaluate the synergistic therapeutic effects of combining Traditional Chinese Medicine (TCM) warm acupuncture with vonoprazan in the treatment of gastroesophageal reflux disease (GERD).Methods: This study enrolled 80 GERD patients admitted to our hospital from January 2024 to January 2025, who were randomly divided into a control group (40 cases) and a treatment group (40 cases). The baseline treatment for both groups was oral vonoprazan fumarate tablets (20 mg once daily [qd]) for 4 weeks. The treatment group additionally received warm acupuncture therapy three times per week over the same duration. Efficacy was assessed using TCM syndrome scores, standardized evaluations via the Reflux Disease Questionnaire (RDQ) and Gastroesophageal Reflux Disease Questionnaire (GerdQ), endoscopic esophageal inflammation grading (Los Angeles [LA] classification), and the effective rate of TCM symptom improvement.Results: After 4 weeks of treatment, both groups showed statistically significant improvements in TCM syndrome scores (P=0.002) and questionnaire scores (RDQ: P=0.000; GerdQ:P=0.000 ). The total effective rate in the treatment group (100.0%) was superior to that of the control group (90.0%) (P=0.012). Endoscopic evaluation revealed that the treatment group achieved a significantly higher effective rate of inflammatory resolution (97.5%) compared to the control group (65.0%) (P=0.001).Conclusion: The combination of warm acupuncture and vonoprazan demonstrates synergistic efficacy in alleviating clinical symptoms, improving quality of life, and promoting pathological recovery in GERD patients. This integrated protocol holds significant clinical value and is recommended as an optimized therapeutic strategy for broader application. |
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