| 欧阳雄峰.司库奇尤单抗单药皮下注射与阿维A胶囊治疗寻常型斑块状银屑病的临床疗效对照观察[J].浙江中西医结合杂志,2026,36(4): |
| 司库奇尤单抗单药皮下注射与阿维A胶囊治疗寻常型斑块状银屑病的临床疗效对照观察 |
| Clinical efficacy of scuccizumab monotherapy subcutaneous injection versus avidin capsules in the treatment of common plaque psoriasis: a controlled observation |
| 投稿时间：2025-05-01 修订日期：2025-12-09 |
| DOI： |
| 中文关键词: 司库奇尤单抗 寻常型斑块状银屑病 阿维A胶囊 皮肤生理屏障功能 疗效 |
| 英文关键词:Streptokinumab Ordinary plaque psoriasis Avicenna capsule Skin physiologic barrier function Efficacy |
| 基金项目:海盐县卫健局科研项目(2023ws022) |
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| 中文摘要: |
:目的 观察司库奇尤单抗单药皮下注射与阿维A胶囊治疗寻常型斑块状银屑病的临床疗效。方法 选取2023年6月～2024年10月收治的90例寻常型斑块状银屑病患者为研究对象,采用随机数字表法分为两组。阿维A组45例给予阿维A胶囊治疗,单抗组45例给予司库奇尤单抗单药皮下注射治疗。比较两组皮肤生理屏障功能、程序性死亡蛋白-1(PD-1)mRNA、程序性死亡蛋白配体-1(PD-L1)mRNA、CD4+T淋巴细胞群、银屑病面积与严重程度指数(PASI)评分、皮肤病生活质量指数(DLQI)、临床总有效率、不良反应发生率。结果 两组治疗前皮肤生理屏障功能比较,差异无统计学意义(P>0.05)。两组治疗后经表皮水分丢失量均降低,但单抗组治疗后低于阿维A组(P<0.05)。单抗组治疗后皮脂含量、角质层含水量均升高,但单抗组治疗后高于阿维A组(P<0.05)。两组治疗前PD-1mRNA、PD-L1mRNA比较,差异无统计学意义(P>0.05)。两组治疗后PD-1mRNA、PD-L1mRNA均降低,但单抗组治疗后低于阿维A组(P<0.05)。两组治疗前CD4+T淋巴细胞群比较,差异无统计学意义(P>0.05)。两组治疗后Th1细胞比例均降低,但单抗组治疗后低于阿维A组(P<0.05)。两组治疗后Th2细胞比例、Treg细胞比例均升高,但单抗组治疗后高于阿维A组(P<0.05)。两组治疗前DLQI评分、PASI评分比较,差异无统计学意义(P>0.05)。两组治疗后DLQI评分、PASI评分均降低,但单抗组治疗后低于阿维A组(P<0.05)。单抗组临床总有效率高于阿维A组(P<0.05),但单抗组总不良反应发生率与阿维A组比较,差异无统计学意义(P>0.05)。结论 司库奇尤单抗单药皮下注射治疗寻常型斑块状银屑病疗效优于阿维A胶囊,可改善CD4+T淋巴细胞群与皮肤生理屏障功能。 |
| 英文摘要: |
| Objective To observe the clinical efficacy of subcutaneous injection of stuccizumab monotherapy versus avitamin A capsules in the treatment of unusual plaque psoriasis.Methods Ninety cases of patients with normal plaque psoriasis admitted from June 2023 to October 2024 were selected for the study and were divided into two groups using randomized numerical table method. Forty-five cases in the Avicenna group were treated with Avicenna capsules, and 45 cases in the monoclonal antibody group were treated with subcutaneous injections of secukinumab monotherapy. The two groups were compared in terms of skin physiological barrier function, programmed death protein-1 (PD-1) mRNA, programmed death protein ligand-1 (PD-L1) mRNA, CD4+ T-lymphocyte population, psoriasis area and severity index (PASI) scores, dermatologic quality of life index (DLQI), overall clinical efficiency, and incidence of adverse reactions.Results Comparison of the physiological barrier function of the skin before treatment between the two groups showed no statistically significant difference (P>0.05). The amount of transepidermal water loss was reduced in antibody group after treatment, but it was lower in the monoclonal antibody group than in the Avi A group after treatment (P<0.05). Sebum content and stratum corneum water content increased after treatment in both groups, but it was higher in the monoclonal antibody group than in the AviA group after treatment (P<0.05). Comparison of PD-1mRNA and PD-L1mRNA before treatment in the two groups showed no statistically signific |
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