| 朱肖肖.合募配穴热敏灸联合疏肝解郁消痞方治疗肝胃不和型功能性消化不良合并睡眠不良的临床研究[J].浙江中西医结合杂志,2026,36(4): |
| 合募配穴热敏灸联合疏肝解郁消痞方治疗肝胃不和型功能性消化不良合并睡眠不良的临床研究 |
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| 投稿时间：2025-05-13 修订日期：2026-03-17 |
| DOI： |
| 中文关键词: 功能性消化不良 合募配穴 热敏灸 胃肠激素 脑肠肽 |
| 英文关键词: |
| 基金项目:湖州市科技计划项目(2023GY64) |
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| 中文摘要: |
| 【】目的 ?观察合募配穴热敏灸联合疏肝解郁消痞方治疗肝胃不和型功能性消化不良(FD)合并睡眠不良的临床疗效及安全性,并评估其对胃肠激素、脑肠肽及炎症因子的影响。方法 ??将120例患者随机分为观察组(疏肝解郁消痞方+合募配穴热敏灸)与对照组(多潘立酮片+模拟灸),每组60例,疗程1个月。比较两组总有效率、中医证候评分、尼平消化不良症状指数(NDSI)、生活质量指数(NDLQI)、匹兹堡睡眠质量指数(PSQI),检测胃肠激素(MLT、GAS、Ghrelin)、脑肠肽(VIP、5-HT、SP)及炎症因子(IL-6、TNF-α)水平,记录不良反应及6个月随访复发率。结果 ? 观察组总有效率95.0%(对照组85.0%,P<0.05)。治疗后,观察组NDSI、PSQI评分及GAS、VIP、SPIL-6、TNF-α水平显著低于对照组(P<0.05),NDLQI评分及MLT、Ghrelin和5-HT水平高于对照组(P<0.05)。观察组6个月复发率低于对照组(10.0% vs 28.33%,P<0.05)。两组不良反应率差异没有统计学意义(P＞0.05)。结论? 合募配穴热敏灸联合疏肝解郁消痞方可显著改善肝胃不和型FD合并睡眠不良患者的临床症状及睡眠质量,调节胃肠激素与脑肠肽平衡,抑制炎症反应,且安全性高、复发率低。 |
| 英文摘要: |
| 【】 Objective ?To observe the clinical efficacy and safety of combined treatment with heat-sensitive moxibustion at the paired He-Mu points and the formula for soothing the liver, resolving depression and eliminating distension in the treatment of functional dyspepsia (FD) of liver-stomach disharmony type complicated with poor sleep, and to evaluate its effects on gastrointestinal hormones, brain-gut peptides and inflammatory factors. Methods One hundred and twenty patients were randomly divided into the observation group (Shugan Jieyu Xiaopui Formula + Hemu Combined acupoint heat-sensitive moxibustion) and the control group (dorperidone Tablets + simulated moxibustion), with 60 cases in each group, and the treatment course was one month.The total effective rate, TCM syndrome score, Nepean Dyspepsia Symptom Index (NDSI), Nepean Dyspepsia Quality of Life Index (NDLQI), Pittsburgh Sleep Quality Index (PSQI), levels of gastrointestinal hormones (MLT, GAS, Ghrelin), brain-gut peptides (VIP, 5-HT, SP) and inflammatory factors (IL-6, TNF-α) were compared between the two groups. Adverse reactions and the recurrence rate at 6 months were recorded. Results The total effective rate of the observation group was 95.0% (85.0% of the control group, P<0.05). After treatment, the NDSI, PSQI scores, and the levels of GAS, VIP, SPIL-6, and TNF-α in the observation group were significantly lower than those in the control group (P<0.05), while the NDLQI score and the levels of MLT, Ghrelin, and 5-HT were higher than those in the control group (P<0.05). The recurrence rate in the observation group at 6 months was lower than that in the control group (10.0% vs 28.33%, P<0.05). There was no statistically significant difference in the rate of adverse reactions between the two groups (P > 0.05). Conclusion The combined treatment with heat-sensitive moxibustion at the paired He-Mu points and the formula for soothing the liver, resolving depression and eliminating distension can significantly improve the clinical symptoms and sleep quality of patients with FD of liver-stomach disharmony type complicated with poor sleep, regulate the balance of gastrointestinal hormones and brain-gut peptides, inhibit inflammatory responses, and has high safety and low recurrence rate. |
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