| 宋王珍.单核细胞/淋巴细胞比值与围绝经期及绝经后女性代谢综合征的相关关系研究[J].浙江中西医结合杂志,2026,36(7): |
| 单核细胞/淋巴细胞比值与围绝经期及绝经后女性代谢综合征的相关关系研究 |
| Association Between Monocyte-to-Lymphocyte Ratio and Metabolic Syndrome in Perimenopausal and Postmenopausal Women |
| 投稿时间：2025-05-22 修订日期：2026-06-02 |
| DOI： |
| 中文关键词: 单核细胞/淋巴细胞比值 围绝经期 绝经后 代谢综合征 炎症指标 |
| 英文关键词:Monocyte-to-Lymphocyte Ratio Perimenopause Postmenopause Metabolic Syndrome Inflammatory Marker |
| 基金项目: |
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| 中文摘要: |
| 目的 研究单核细胞/淋巴细胞比值(MLR)与围绝经期及绝经后女性代谢综合征(MS)的相关关系。方法 回顾性收集我院于2021年10月-2024年10月诊治的160例围绝经期及绝经后女性MS患者作为研究组,另收集同期160例围绝经期及绝经后女性作为对照组。比较两组相关临床资料,并分析MLR与MS的相关性。结果 研究组年龄、体质量指数、产次、MLR、白细胞计数、尿酸与对照组相比,具有显著性差异(P＜0.05)；MLR、白细胞计数、尿酸是围绝经期及绝经后女性发生MS的独立危险因素(OR值＞1)；MLR与体质量指数(r=0.418,P＜0.001)、白细胞计数(r=0.465,P＜0.001)及尿酸(r=0.437,P＜0.001)呈显著正相关。ROC曲线结果发现,MLR、白细胞计数、尿酸单独及联合预测的AUC值分别为0.878、0.832、0.886、0.973。结论 MLR是一种新兴的炎症标志物,与围绝经期及绝经后女性MS具有一定相关性,联合白细胞计数、尿酸可有效提升预测价值。 |
| 英文摘要: |
| Objective: To investigate the association between the monocyte-to-lymphocyte ratio (MLR) and metabolic syndrome (MS) in perimenopausal and postmenopausal women.
Methods: A retrospective study was conducted on 160 perimenopausal and postmenopausal women diagnosed with MS in our hospital between October 2021 and October 2024 (study group), and 160 age-matched women without MS during the same period (control group). Clinical data were compared between the two groups, and the correlation between MLR and MS was analyzed.
Results: The study group showed significantly higher age, body mass index (BMI), parity, MLR, white blood cell count, and uric acid levels compared to the control group (P < 0.05). MLR, white blood cell count, and uric acid were identified as independent risk factors for MS in perimenopausal and postmenopausal women (OR > 1). MLR was positively correlated with BMI (r = 0.418, P < 0.001), white blood cell count (r = 0.465, P < 0.001), and uric acid (r = 0.437, P < 0.001). ROC curve analysis revealed that the area under the curve (AUC) for MLR, white blood cell count, uric acid, and their combination in predicting MS were 0.878, 0.832, 0.886, and 0.973, respectively. Conclusion: MLR, as a novel inflammatory marker, is significantly associated with MS in perimenopausal and postmenopausal women. Combined assessment with white blood cell count and uric acid can enhance predictive accuracy. |
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