| 冯俊凯,胡超海,汪翼凡,金阳辉,马鹏飞,杨家漩,刘飞,周子懿,汪忠强,陈思齐.当归六黄汤治疗阴虚内热型脊柱结核的临床疗效观察[J].浙江中西医结合杂志,2026,36(6): |
| 当归六黄汤治疗阴虚内热型脊柱结核的临床疗效观察 |
| Clinical Efficacy Observation of Danggui Liuhuang Decoction in Treating Spinal Tuberculosis of Yin Deficiency with Internal Heat Pattern |
| 投稿时间：2025-08-05 修订日期：2026-05-19 |
| DOI： |
| 中文关键词: 当归六黄汤 脊柱结核 中药治疗 |
| 英文关键词:Danggui Liuhuang Decoction Spinal Tuberculosis Traditional Chinese Medicine Treatment |
| 基金项目:浙江省中医药科研基金计划（浙江省中医药管理局课题） |
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| 中文摘要: |
| 评价当归六黄汤治疗阴虚内热型脊柱结核疗效分析。方法:将脊柱结核病人随机分为2组,每组30例,治疗组使用常规四联抗结核药物+当归六黄汤4周,对照组仅常规四联抗结核药物(即异烟肼0.3g/次、利福平0.6g/次、乙胺丁醇0.75g/次,每日一次,吡嗪酰胺0.5g/次,每日三次)。当归六黄汤使用当归6g、生地黄6g、熟地黄6g、黄芩6g、黄柏6g、黄连6g、黄芪12g,日1剂,每日两次煎服。收集并分析两组患者用药后疼痛视觉模拟评分(VAS)、功能障碍指数评分(ODI)、血红细胞沉降率(ESR)、C反应蛋白(CRP)、白细胞介素10(IL-10),人干扰素-伽马(IFN-γ),人肿瘤坏死因子(TNF-α)的变化情况,以及中医证候评分。结果:研究结果显示,经过治疗后,治疗组的有效率为96.70%(29/30),而对照组的有效率为80.00%(24/30),治疗组在临床疗效上显著优于对照组(P＜0.05)。其中治疗组对患者的临床症状有所改善,治疗结束后,两组患者疼痛、倦怠乏力、潮热、口干咽燥、盗汗、中医证候总积分均下降,治疗组比对照组具有统计学意义(P＜0.05),在潮热盗汗两组比较中,治疗组疗效显著。两组食欲不振证候积分均上升,治疗组对比对照组无明显统计学差异(P＞0.05)。同时治疗后,两组患者的VAS、ODI评分均有改善(P＜0.05),其中治疗组的改善程度较对照组更为突出(P＜0.05)。 |
| 英文摘要: |
| Evaluation of the therapeutic effect of Danggui Liuhuang Tang on spinal tuberculosis of yin deficiency and internal heat type. Methods: The patients with spinal tuberculosis were randomly divided into two groups, 30 cases in each group. The treatment group was treated with conventional quadruple anti tuberculosis drugs+Danggui Liuhuang Decoction for 4 weeks, while the control group was treated with conventional quadruple anti tuberculosis drugs (i.e. isoniazid 0.3 g/time, rifampicin 0.6 g/time, ethambutol 0.75 g/time, once a day, pyrazinamide 0.5 g/time, three times a day). Danggui Liuhuang Tang is made by taking 6g Danggui, 6g Shengdihuang, 6g Dihuang, 6g Huangqin, 6g Huangbai, 6g Huanglian, and 12g Huangqi, once a day, and decocting twice a day. Collect and analyze the changes in pain visual analog scale (VAS), functional impairment index (ODI), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), interleukin-10 (IL-10), human interferon gamma (IFN - γ), human tumor necrosis factor alpha (TNF - α), and traditional Chinese medicine syndrome score in two groups of patients after medication. Result: The research results showed that after treatment, the effective rate of the treatment group was 96.70% (29/30), while the effective rate of the control group was 80.00% (24/30). The clinical efficacy of the treatment group was significantly better than that of the control group (P<0.05). The treatment group showed some improvement in the clinical symptoms of the patients. After the end of treatment, the total scores of pain, fatigue, hot flashes, dry mouth and throat, night sweats, and traditional Chinese medicine syndrome in both groups decreased. The treatment group had statistical significance compared with the control group (P<0.05). In the comparison of hot flashes and night sweats between the two groups, the treatment group had significant therapeutic effects. Both groups showed an increase in the score of loss of appetite syndrome, and there was no significant statistical difference between the treatment group and the control group (P>0.05). After simultaneous treatment, both groups of patients showed improvement in VAS and ODI scores (P<0.05), with the treatment group showing a more significant improvement compared to the control group (P<0.05). |
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