| 项盛,包洁,范永升.基于数据挖掘探讨范永升治疗强直性脊柱炎学术经验及用药规律[J].浙江中西医结合杂志,2026,36(6): |
| 基于数据挖掘探讨范永升治疗强直性脊柱炎学术经验及用药规律 |
| FAN Yongsheng’s experience in treating ankylosing spondylitis with the concept of ‘kidney-tonifying and collaterals-unblocking’ |
| 投稿时间：2025-10-23 修订日期：2026-01-06 |
| DOI： |
| 中文关键词: 范永升 益肾通络 强直性脊柱炎 数据挖掘 名医经验 |
| 英文关键词:Fan yongsheng Kidney- tonifying and collaterals-unblocking Ankylosing spondylitis Data Mining Famous doctor’s experience |
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| 中文摘要: |
| 目的:运用数据挖掘技术探析范永升教授治疗强直性脊柱炎（Ankylosing spondylitis，AS）的用药规律及学术思想。方法:收集2020年1月至2023年6月期间于范师门诊就诊、符合纳排标准的AS患者病案，并构建数据库。应用SPSS软件对患者性别、年龄、证型，以及中药使用频次、功效分类、聚类、复杂网络等进行数据挖掘。结果:共纳入108例患者，其中男性66例，女性42例，平均年龄（40.5±13.64）岁。共出现144味中药，其中高频药物31味，以补虚药、祛风湿药、利水渗湿药、解表药为主。肾虚督寒、湿热痹阻、肝肾不足证分别治以“益肾通络蠲痹方”合黄芪桂枝五物汤、术附汤加减，合四妙散化裁，合六味地黄丸、芍药甘草汤加减。结论:范师认为，AS发病以肾虚为本，治疗以益肾通络为基本治则，扶正祛邪并用，“益肾通络蠲痹方”为基础方。范师在临证中注重谨守病机，辨证精准，经方时方并举，用药精炼，反映了其辨证施治、灵活变通的中医临床思维。 |
| 英文摘要: |
| Objective: Applying data mining techniques to analyze Professor Fan Yongsheng's medication patterns and academic philosophy in the treatment of ankylosing spondylitis (AS). Methods: Collect the medical records of AS patients who met the criteria for dispensing in the outpatient department of Fan from January 2020 to June 2023, and a database was established. SPSS software was used to perform data mining on patient gender, age, TCM syndrome types, as well as the frequency of herb use, efficacy-based classification, clustering, and complex network analysis. Results: A total of 108 patients were included, comprising 66 males and 42 females, with a mean age of 40.5 ± 13.64 years. A total of 144 Chinese herbal medicines appeared, including 31 high-frequency medicines, with deficiency-reinforcing medicines, wind dampness-removing medicines, urination-promoting and dampness-draining medicines, and exterior-releasing medicines. Kidney deficiency with du meridian cold, damp heat obstruction, liver-kidney deficiency pattern were treated with " kidney-tonifying, collaterals-unblocking, and impediment-eliminating formula " combined with Astragalus and Cinnamon Twig Five Ingredients Decoction, Modified White Atractylodes and Aconite Decoction, Mysterious Four Powder, Six-Ingredient Rehmannia Pill and Peony and Licorice Decoction respectively. Conclusion: Kidney-tonifying and collaterals-unblocking is the basic treatment principle of AS, and the combination of strengthening and dispelling evil is adopted. "kidney-tonifying, collaterals-unblocking, and impediment-eliminating formula" is the basic prescription. Fan pays attention to observe the pathogenesis of disease in clinical diagnosis, makes precise differentiation of syndrome, combines Classic prescription and Non-classical Prescriptions, and uses refined medicine, which reflects his clinical thinking of TCM in syndrome differentiation and treatment and flexibility. |
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