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| 银屑病与雌激素关联性的研究综述及探索 |
| Review and Exploration of the Correlation between Psoriasis and Estrogen |
| 投稿时间：2026-01-26 修订日期：2026-04-01 |
| DOI： |
| 中文关键词: 银屑病 雌激素 流行病学 发病机制 综述 |
| 英文关键词:Psoriasis Estrogen Epidemiology Pathogenesis Review |
| 基金项目: |
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| 中文摘要: |
| 银屑病是一种以IL-23/IL-17信号轴为核心的慢性炎症性皮肤病，近年来性别差异在疾病发生发展中的影响备受关注；雌激素作为女性核心激素，其水平随生理阶段的自然波动与银屑病严重程度高度关联，提示雌激素深度参与银屑病的病理生理进程，但其机制尚未明确。本文系统梳理银屑病与雌激素的流行病学、发病机制、治疗策略等最新进展，为完善银屑病与雌激素相关的个体化防治提供理论依据与实践参考。 |
| 英文摘要: |
| Psoriasis is a chronic inflammatory skin disease centered on the IL 23/IL 17 signaling axis. In recent years, the influence of gender differences on the occurrence and progression of this disease has attracted considerable attention. As a key female hormone, estrogen naturally fluctuates across different physiological stages, and its levels are closely associated with the severity of psoriasis, suggesting that estrogen is deeply involved in the pathophysiological process of psoriasis, although its underlying mechanism remains unclear. This article systematically reviews the latest advances in epidemiology, pathogenesis, and therapeutic strategies related to psoriasis and estrogen, aiming to provide a theoretical basis and practical reference for improving the individualized prevention and treatment of estrogen associated psoriasis. |
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