| Objective: To investigate the clinical efficacy of a medicinal bath formulation containing Yinchen Tuihuang Jianspi combined with massage of the Yanglingquan acupoint in the treatment of neonatal jaundice (NNJ) (characterised by the pattern of damp-heat stagnation), and its effects on oxidative stress and inflammatory responses. Methods: A total of 154 paediatric patients with neonatal jaundice (NNJ) admitted to Pingdingshan Hospital of Traditional Chinese Medicine between January 2023 and July 2025 were selected and randomised using a random number table into an observation group and a control group, each comprising 77 patients. The control group received conventional blue light phototherapy combined with massage of the Yanglingquan acupoint, whilst the observation group received the same treatment as the control group supplemented with herbal baths using the Yinchen Tuihuang Jianspi Formula. Clinical status, serum bilirubin levels, oxidative stress and inflammatory markers were assessed in both groups, and the incidence of adverse reactions during treatment was recorded. Results: The treatment efficacy in the observation group was higher than that in the control group (P < 0.05); the time to resolution of jaundice, the time until stools turned yellow, the duration of phototherapy, and the length of hospital stay were all shorter in the observation group than in the control group (P < 0.05); Prior to treatment, there were no statistically significant differences between the two groups in total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), malondialdehyde (MDA), C-reactive protein (CRP), interleukin-6 (IL-6) or superoxide dismutase (SOD) levels (P > 0.05); post-treatment, the levels of TBIL, DBIL and IBIL in the observation group were lower than those in the control group (P < 0.05); post-treatment, MDA, CRP and IL-6 levels decreased in both groups, with the observation group showing lower levels than the control group (P < 0.05); post-treatment, SOD levels in both groups were lower than pre-treatment levels, but the observation group had higher post-treatment SOD levels than the control group (P < 0.05); There was no statistically significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion: The combination of herbal bath therapy using the Yinchen Tuihuang Jianspi Formula and massage of the Yanglingquan acupoint demonstrates significant efficacy in the treatment of neonatal jaundice (damp-heat stagnation syndrome). It effectively improves clinical symptoms in infants, reduces serum bilirubin levels, and alleviates oxidative stress damage and inflammatory responses, whilst exhibiting good safety. This approach provides an effective integrated traditional Chinese and Western medicine treatment strategy for neonatal jaundice. |
