| Osteosarcoma is one of the most common primary malignant bone tumors and is characterized by strong invasiveness, a high tendency for recurrence and metastasis, and poor prognosis. Although comprehensive treatment strategies based on neoadjuvant chemotherapy combined with surgical resection have improved patient outcomes to some extent, recurrence, metastasis, and chemoresistance remain major challenges in current clinical management. In recent years, metabolic reprogramming has gradually become an important focus in osteosarcoma research, among which glycolytic reprogramming is considered a crucial metabolic basis for the rapid proliferation, invasion, metastasis, stemness maintenance, and therapeutic resistance of osteosarcoma cells. Traditional Chinese medicine, characterized by multi-component, multi-target, and multi-pathway synergistic regulation, has shown certain advantages in the prevention and treatment of osteosarcoma. Some studies have shown that it can inhibit the proliferation, migration, and invasion of osteosarcoma cells and induce apoptosis, ferroptosis, and other processes by regulating glycolysis-related key enzymes, the PI3K/AKT signaling axis, and other metabolism-related networks. This article reviews the biological basis of glycolytic reprogramming in osteosarcoma, the research progress of traditional Chinese medicine targeting glycolytic reprogramming in osteosarcoma, as well as the advantages and limitations of this strategy, with the aim of providing references for clarifying the metabolic mechanisms of traditional Chinese medicine against osteosarcoma, expanding the therapeutic strategies targeting metabolism in osteosarcoma, and promoting further research in this field. |
