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柴树人.葛根芩连五炭汤联合西药治疗活动期溃疡性结肠炎患者临床疗效观察及其安全性评价[J].浙江中西医结合杂志,2018,28(3):
葛根芩连五炭汤联合西药治疗活动期溃疡性结肠炎患者临床疗效观察及其安全性评价
Gegen Qinlian Wutan soup combine with western medicine treatment active ulcerative colitis clinical efficacy and observe safety evaluation
投稿时间:2016-07-25  修订日期:2018-02-06
DOI:
中文关键词:  葛根芩连五炭汤  西药  活动期溃疡性结肠炎  疗效  安全性
英文关键词:Gegen Qinlian Wutan soup  medicine  active ulcerative colitis  efficacy  safety
基金项目:
作者单位E-mail
柴树人* 宁波市中医院 chaishuren672@163.com 
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中文摘要:
      目的:探讨葛根芩连五炭汤联合西药治疗活动期溃疡性结肠炎患者临床疗效及其安全性评价。方法:选自我院于2013年3月~2016年3月期间收治的活动期溃疡性结肠炎患者82例,依据随机数字表法随机分为观察组41例与对照组41例。对照组给予西药治疗,观察组在对照组基础上结合葛根芩连五炭汤治疗。两组疗程均为4周。比较两组治疗疗效,治疗前后溃疡性结肠炎活动度评分、血浆炎症因子水平变化,及不良反应发生情况。结果:观察组治疗总有效率(92.68%)高于对照组(70.73%)(P<0.05);两组活动度评分治疗后下降(P<0.05);观察组活动度评分治疗后低于对照组(P<0.05);两组血浆IL-6和TNF-α治疗后下降(P<0.05);观察组血浆IL-6和TNF-α治疗后低于对照组(P<0.05);两组心电图、血常规、尿常规、肝肾功能均未见异常,且无明显药物不良反应。结论:葛根芩连五炭汤联合西药治疗活动期溃疡性结肠炎患者临床疗效显著,安全可靠,值得研究。
英文摘要:
      Objective: To investigate Gegen Qinlian Wutan soup combine with western medicine treatment active ulcerative colitis clinical efficacy and observe safety evaluation. Methods: selected from our hospital in March 2013 to March 2016 ulcerative colitis patients 82 cases, were randomly divided into two groups 41 cases 41 cases and the control group. Control group was given western medicine, combined with the observation group Gegen Qinlian Wutan soup treated in the control group basis. The treatment lasted 4 weeks. Comparison of the efficacy of treatment in both groups, before and after the treatment of ulcerative colitis activity score, plasma levels of inflammatory factors, and adverse events. Results: The observation group total effective observation group (92.68%) was higher (70.73%) (P<0.05); two groups activity score decreased after treatment (P<0.05); the observation group activity score after treatment than control group (P<0.05); the latter two groups decreased plasma IL-6 and TNF-α treatment (P<0.05); observation of plasma IL-6 and TNF-α after treatment than the control group (P<0.05); two groups electrocardiogram, blood, urine, liver and kidney functions were normal, and no significant adverse drug reactions. Conclusion: The clinical efficacy of Gegen Qinlian Wutan soup combine with western medicine treatment of active ulcerative colitis patients with five carbon soup significant, safe and reliable, worthy of study.
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